SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5voh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 8 SER A 280
ALA A 260
ILE A 261
ASN A 258
 None
 1.00A 1pnlA-5vohA:
undetectable
1pnlB-5vohA:
undetectable		 1pnlA-5vohA:
18.74
1pnlB-5vohA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 7 ASP A 234
ALA A 147
GLY A 170
THR A 151
 None
 0.80A 1t7jB-5vohA:
undetectable		 1t7jB-5vohA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 TYR A 199
LEU A 329
ILE A 334
ALA A 163
PHE A 187
 None
 1.42A 2qo4A-5vohA:
undetectable		 2qo4A-5vohA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 HIS A 171
GLY A 170
GLY A  49
CYH A 131
ASP A 143
 None
None
None
FAD  A 501 (-3.6A)
None
 1.14A 3keeA-5vohA:
undetectable		 3keeA-5vohA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 7 GLU A 164
LEU A  46
LYS A  51
ALA A  45
 None
 1.12A 3mbgA-5vohA:
undetectable
3mbgB-5vohA:
undetectable		 3mbgA-5vohA:
13.81
3mbgB-5vohA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 10 SER A 374
ALA A 344
LEU A 339
GLY A 386
ALA A 256
 None
 1.25A 4fe1A-5vohA:
undetectable
4fe1J-5vohA:
undetectable		 4fe1A-5vohA:
21.33
4fe1J-5vohA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 10 SER A 374
ALA A 344
LEU A 339
GLY A 386
ALA A 260
 None
 1.24A 4fe1A-5vohA:
undetectable
4fe1J-5vohA:
undetectable		 4fe1A-5vohA:
21.33
4fe1J-5vohA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 6 LEU A 385
GLY A 386
VAL A 376
ALA A 351
 None
 0.19A 4o0wA-5vohA:
undetectable		 4o0wA-5vohA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 TYR A 318
ALA A 277
GLY A 304
ASN A 299
GLY A 112
 None
None
None
None
FAD  A 501 (-2.6A)
 1.25A 4obwA-5vohA:
undetectable		 4obwA-5vohA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 TYR A 318
ALA A 277
GLY A 304
ASN A 299
GLY A 112
 None
None
None
None
FAD  A 501 (-2.6A)
 1.25A 4obwD-5vohA:
undetectable		 4obwD-5vohA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 8 SER A 336
ALA A 343
LEU A 339
GLY A 386
 None
 0.99A 4xk8a-5vohA:
undetectable		 4xk8a-5vohA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 8 ALA A 277
GLY A 304
ALA A  15
GLY A  12
 None
 0.65A 4zjzA-5vohA:
undetectable		 4zjzA-5vohA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 8 SER A 280
GLY A 278
ILE A  16
GLY A 304
 None
FAD  A 501 (-3.0A)
None
None
 0.81A 5alcL-5vohA:
undetectable		 5alcL-5vohA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 6 LEU A 235
CYH A 131
HIS A 136
LEU A 140
 None
FAD  A 501 (-3.6A)
None
None
 1.17A 5hpuC-5vohA:
undetectable
5hpuD-5vohA:
undetectable		 5hpuC-5vohA:
4.08
5hpuD-5vohA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 11 VAL A   6
GLY A   7
GLU A  32
LEU A 248
ASN A 245
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-2.4A)
FAD  A 501 (-4.7A)
FAD  A 501 (-2.8A)
 1.11A 5x6yA-5vohA:
2.4		 5x6yA-5vohA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 11 VAL A   6
GLY A   7
GLU A  32
LEU A 248
ASN A 245
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-2.4A)
FAD  A 501 (-4.7A)
FAD  A 501 (-2.8A)
 1.09A 5x6yC-5vohA:
undetectable		 5x6yC-5vohA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 ARG A 383
LEU A 385
GLY A 386
VAL A 376
ALA A 351
 None
 0.64A 5xv7A-5vohA:
undetectable		 5xv7A-5vohA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 12 ALA A 388
GLY A 386
GLY A 338
LEU A 372
PHE A 191
 None
None
None
EDO  A 503 (-3.2A)
None
 1.12A 5ybbA-5vohA:
undetectable		 5ybbA-5vohA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		4 / 7 SER A 111
SER A 280
GLY A 278
LEU A 249
 FAD  A 501 (-4.5A)
None
FAD  A 501 (-3.0A)
None
 1.14A 6btxA-5vohA:
undetectable		 6btxA-5vohA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 11 TYR A 285
SER A 325
SER A 336
THR A 337
TYR A 186
 None
NDP  A 502 (-4.5A)
None
None
NDP  A 502 (-4.7A)
 1.25A 6d6tD-5vohA:
undetectable
6d6tE-5vohA:
undetectable		 6d6tD-5vohA:
20.70
6d6tE-5vohA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5voh NADH OXIDASE
(Lactobacillus
brevis) 		5 / 11 VAL A 108
THR A 110
VAL A 312
LEU A 311
ALA A  11
 None
None
None
None
FAD  A 501 (-3.2A)
 1.10A 6dryA-5vohA:
undetectable		 6dryA-5vohA:
23.02