SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		6 / 10 GLY A  65
SER A 152
MET A 153
LEU A 178
LEU A 238
HIS A 265
 None
None
None
IPA  A 303 ( 4.5A)
None
None
 1.02A 1a8uA-5volA:
15.0		 1a8uA-5volA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		6 / 10 GLY A  65
SER A 152
MET A 153
LEU A 178
LEU A 238
HIS A 265
 None
None
None
IPA  A 303 ( 4.5A)
None
None
 1.00A 1a8uB-5volA:
14.7		 1a8uB-5volA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		4 / 8 PHE A  44
LEU A  62
ALA A 149
VAL A 281
 None
 0.88A 1epbB-5volA:
undetectable		 1epbB-5volA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 11 LEU A 130
TYR A  61
ALA A 102
GLY A 112
PHE A 169
 None
 1.08A 1l5rA-5volA:
4.0		 1l5rA-5volA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 12 TYR A 113
LEU A  63
ALA A 102
PHE A 169
HIS A 165
 None
None
None
None
IPA  A 304 (-3.7A)
 1.33A 2qo4A-5volA:
undetectable		 2qo4A-5volA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 12 TYR A 113
LEU A  63
ALA A 102
PHE A 169
HIS A 165
 None
None
None
None
IPA  A 304 (-3.7A)
 1.33A 2qo6A-5volA:
undetectable		 2qo6A-5volA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		3 / 3 MET A 179
VAL A 212
GLU A 244
 None
 0.60A 3c6gA-5volA:
undetectable		 3c6gA-5volA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 9 LEU A  62
GLY A 155
ALA A 158
GLY A 112
THR A  99
 None
 1.07A 3gguB-5volA:
undetectable		 3gguB-5volA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		4 / 8 ASN A 160
LEU A 223
SER A 166
HIS A 165
 None
None
None
IPA  A 304 (-3.7A)
 1.10A 3kp2A-5volA:
undetectable
3kp2B-5volA:
undetectable		 3kp2A-5volA:
18.37
3kp2B-5volA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		3 / 3 GLU A 122
GLU A 205
ASN A 206
 None
 0.91A 3lp9B-5volA:
undetectable
3lp9D-5volA:
undetectable		 3lp9B-5volA:
22.30
3lp9D-5volA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		4 / 6 PHE A 169
TYR A 161
VAL A  98
PHE A 125
 None
 1.15A 3ltwA-5volA:
undetectable		 3ltwA-5volA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 10 ILE A 133
SER A 152
TRP A 270
ALA A 158
LEU A  63
 None
 1.33A 3lw5B-5volA:
undetectable		 3lw5B-5volA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 12 HIS A 265
ASP A 236
GLY A  65
SER A 152
ASP A 231
 None
 0.85A 3sueC-5volA:
undetectable		 3sueC-5volA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		5 / 12 GLY A 155
GLY A 150
LEU A  62
GLU A  68
LEU A 238
 None
 1.18A 3vywA-5volA:
undetectable		 3vywA-5volA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		4 / 7 TRP A  73
GLY A 157
GLY A 156
MET A 179
 None
 1.03A 4fgkB-5volA:
undetectable		 4fgkB-5volA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		3 / 3 ARG A 219
LYS A 210
GLU A 214
 None
 0.76A 5d0yA-5volA:
undetectable		 5d0yA-5volA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		3 / 3 PRO A 279
ARG A 283
GLU A  91
 None
 0.96A 5j6hA-5volA:
undetectable		 5j6hA-5volA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vol PUTATIVE ESTERASE
(Bacteroides
intestinalis) 		3 / 3 GLN A 163
TRP A 228
VAL A 254
 None
 0.83A 6auuA-5volA:
undetectable		 6auuA-5volA:
20.18