SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 VAL A 442
LEU A 481
VAL A 478
LEU A 422
 None
 0.69A 1cqpA-5vopA:
undetectable
1cqpB-5vopA:
undetectable		 1cqpA-5vopA:
21.39
1cqpB-5vopA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 MET A 555
LEU A 368
VAL A 571
GLY A 570
 None
None
None
C2F  A3001 (-3.5A)
 0.85A 1hrkA-5vopA:
undetectable		 1hrkA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 MET A 555
LEU A 368
VAL A 571
GLY A 570
 None
None
None
C2F  A3001 (-3.5A)
 0.86A 1hrkB-5vopA:
undetectable		 1hrkB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 449
VAL A 478
LEU A 481
ALA A 482
ALA A 487
 None
 0.91A 1jinA-5vopA:
undetectable		 1jinA-5vopA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLU A 385
ARG A 374
LYS A 608
ASP A 605
 None
 1.40A 1k4tA-5vopA:
undetectable		 1k4tA-5vopA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ARG A 374
ASP A 531
GLY A 570
SER A 572
ARG A 583
 None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
 1.13A 1q8jA-5vopA:
27.4		 1q8jA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 376
ASP A 411
ASP A 531
GLY A 570
ARG A 583
 NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-3.0A)
 1.46A 1q8jA-5vopA:
27.4		 1q8jA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 443
ASN A 464
GLY A 570
PHE A 535
ILE A 603
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-3.5A)
None
C2F  A3001 (-3.5A)
 1.43A 1q8jA-5vopA:
27.4		 1q8jA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASN A 376
ASP A 443
ASN A 464
ASP A 531
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.39A 1q8jA-5vopA:
27.4		 1q8jA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASN A 376
ASP A 443
ASN A 464
GLY A 570
SER A 572
PHE A 576
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-4.7A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.95A 1q8jA-5vopA:
27.4		 1q8jA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 376
ASN A 464
SER A 465
GLY A 570
SER A 572
 NA  A3005 (-3.0A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
 0.80A 1q8jB-5vopA:
25.6		 1q8jB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASN A 376
ASP A 443
ASN A 464
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.51A 1q8jB-5vopA:
25.6		 1q8jB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLU A 385
ARG A 374
LYS A 608
ASP A 605
 None
 1.45A 1rr8C-5vopA:
undetectable		 1rr8C-5vopA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLU A 385
ARG A 374
LYS A 608
ASP A 605
 None
 1.46A 1rrjA-5vopA:
undetectable		 1rrjA-5vopA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 ALA A 602
LEU A 552
LEU A 591
ARG A 597
ARG A 595
 None
None
None
GOL  A3002 (-2.7A)
None
 1.40A 2ceoB-5vopA:
undetectable		 2ceoB-5vopA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASP A 443
ASN A 464
LEU A 492
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.28A 2e7fA-5vopA:
30.7		 2e7fA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLU A 373
ASN A 464
LEU A 492
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.26A 2e7fB-5vopA:
30.8		 2e7fB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLU A 373
ASP A 443
ASN A 464
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.32A 2ogyA-5vopA:
30.5		 2ogyA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLU A 373
ASP A 443
ASN A 464
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.29A 2ogyB-5vopA:
30.8		 2ogyB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASP A 443
ASN A 464
LEU A 492
ASP A 531
GLY A 570
SER A 572
ASN A 573
ILE A 603
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.5A)
 0.30A 2ycjA-5vopA:
30.6		 2ycjA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 HIS A 431
THR A 434
LEU A 392
LEU A 396
 None
 1.10A 3bgdA-5vopA:
undetectable		 3bgdA-5vopA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 7 LEU A 410
ARG A 400
SER A 380
GLY A 394
MET A 386
 None
None
C2F  A3001 (-4.7A)
None
None
 1.08A 3hcnA-5vopA:
3.4		 3hcnA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 410
ARG A 400
SER A 380
GLY A 394
 None
None
C2F  A3001 (-4.7A)
None
 0.86A 3hcrA-5vopA:
2.1		 3hcrA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A 410
ARG A 400
SER A 380
GLY A 394
 None
None
C2F  A3001 (-4.7A)
None
 0.92A 3hcrB-5vopA:
3.5		 3hcrB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 376
GLY A 379
ASP A 411
VAL A 490
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.43A 3k13A-5vopA:
39.5		 3k13A-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASN A 376
GLY A 379
ASP A 443
VAL A 490
GLY A 570
SER A 572
ASN A 573
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.5A)
 0.29A 3k13A-5vopA:
39.5		 3k13A-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASN A 464
ASP A 531
ARG A 583
 C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.0A)
 0.19A 3k13A-5vopA:
39.5		 3k13A-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 376
GLY A 379
ASP A 411
VAL A 490
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.45A 3k13B-5vopA:
39.6		 3k13B-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		11 / 12 GLU A 373
ASN A 376
GLY A 379
ASP A 443
ASN A 464
VAL A 490
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.33A 3k13B-5vopA:
39.6		 3k13B-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASN A 376
ASP A 443
VAL A 490
GLY A 570
SER A 572
ASN A 573
PHE A 576
ILE A 603
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-4.7A)
C2F  A3001 (-3.5A)
 0.72A 3k13C-5vopA:
39.4		 3k13C-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 376
GLY A 379
ASP A 411
VAL A 490
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.45A 3k13C-5vopA:
39.4		 3k13C-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		10 / 12 GLU A 373
ASN A 376
GLY A 379
ASP A 443
VAL A 490
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.36A 3k13C-5vopA:
39.4		 3k13C-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 415
GLU A 421
ALA A 453
ASP A 443
VAL A 442
 None
None
None
C2F  A3001 (-2.5A)
None
 1.19A 3nvkF-5vopA:
undetectable
3nvkJ-5vopA:
undetectable		 3nvkF-5vopA:
undetectable
3nvkJ-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 376
ASP A 411
LEU A 492
ASP A 531
GLY A 570
ARG A 583
 NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-3.0A)
 1.40A 4djeA-5vopA:
30.1		 4djeA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASN A 376
ASP A 443
LEU A 492
ASP A 531
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.59A 4djeA-5vopA:
30.1		 4djeA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 443
ASP A 531
GLY A 570
ASN A 573
ARG A 583
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.76A 4djeB-5vopA:
30.2		 4djeB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		9 / 12 GLU A 373
ASP A 411
ASP A 443
ASN A 464
ASP A 531
GLY A 570
SER A 572
ASN A 573
ARG A 583
 C2F  A3001 (-3.7A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.61A 4djeB-5vopA:
30.2		 4djeB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLU A 373
ASN A 376
ASP A 531
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.33A 4djfA-5vopA:
30.3		 4djfA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLU A 373
ASP A 411
ASP A 443
ASN A 464
LEU A 492
GLY A 570
SER A 572
ARG A 583
 C2F  A3001 (-3.7A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
 0.57A 4djfB-5vopA:
30.4		 4djfB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 376
ASP A 443
GLY A 570
SER A 572
ILE A 603
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.5A)
 1.16A 4o1eA-5vopA:
28.2		 4o1eA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 GLU A 373
ASN A 376
ASP A 443
LEU A 492
ASP A 531
GLY A 570
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-3.5A)
 0.50A 4o1eA-5vopA:
28.2		 4o1eA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 376
ASP A 443
GLY A 570
SER A 572
ILE A 603
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.5A)
 1.16A 4o1eB-5vopA:
28.0		 4o1eB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 443
LEU A 492
GLY A 570
ASN A 573
ILE A 603
 C2F  A3001 (-2.5A)
None
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.5A)
 0.89A 4o1eB-5vopA:
28.0		 4o1eB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 GLU A 373
ASN A 376
ASP A 443
LEU A 492
GLY A 570
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
None
C2F  A3001 (-3.5A)
C2F  A3001 (-3.5A)
 0.51A 4o1eB-5vopA:
28.0		 4o1eB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 624
LEU A 586
THR A 534
ALA A 548
ILE A 537
 None
 1.13A 4x1yB-5vopA:
undetectable		 4x1yB-5vopA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		10 / 12 GLU A 373
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.23A 5vooA-5vopA:
48.1		 5vooA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ASN A 376
ASP A 411
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 1.41A 5vooA-5vopA:
48.1		 5vooA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 5 ASN A 376
ASP A 443
ASN A 464
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 0.09A 5vooA-5vopA:
48.1		 5vooA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		10 / 12 GLU A 373
ASN A 376
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.5A)
 0.57A 5vooB-5vopA:
47.5		 5vooB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 5 ASP A 443
ASN A 464
ASP A 531
ASN A 573
ARG A 583
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.14A 5vooB-5vopA:
47.5		 5vooB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		10 / 12 GLU A 373
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.37A 5vooC-5vopA:
47.6		 5vooC-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ASN A 376
ASP A 411
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 1.39A 5vooC-5vopA:
47.6		 5vooC-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 5 ASN A 376
ASP A 443
ASN A 464
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 0.13A 5vooC-5vopA:
47.6		 5vooC-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASN A 376
GLY A 379
LYS A 381
ASP A 443
MET A 441
VAL A 490
GLY A 570
PHE A 576
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.8A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 (-4.7A)
 1.46A 5vooD-5vopA:
46.4		 5vooD-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 GLU A 373
ASN A 376
GLY A 379
LYS A 381
ASP A 411
MET A 441
VAL A 490
LEU A 492
GLY A 570
SER A 572
PHE A 576
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-4.7A)
C2F  A3001 (-3.5A)
 0.54A 5vooD-5vopA:
46.4		 5vooD-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 5 ASP A 443
ASN A 464
ASP A 531
ASN A 573
ARG A 583
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.15A 5vooD-5vopA:
46.4		 5vooD-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		11 / 12 GLU A 373
GLY A 379
LYS A 381
ASP A 411
MET A 441
VAL A 490
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.56A 5vooE-5vopA:
46.1		 5vooE-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ASN A 376
ASP A 411
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 1.32A 5vooE-5vopA:
46.1		 5vooE-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 5 ASN A 376
ASP A 443
ASN A 464
ASP A 531
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 0.18A 5vooE-5vopA:
46.1		 5vooE-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 GLU A 373
ASN A 376
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
PHE A 576
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-4.7A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.52A 5vooF-5vopA:
45.7		 5vooF-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ASP A 443
ASN A 464
ASP A 531
ASN A 573
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
 0.09A 5vooF-5vopA:
45.7		 5vooF-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASN A 376
GLY A 379
ASP A 443
VAL A 490
VAL A 568
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.35A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 GLU A 373
ASN A 376
GLY A 379
ASP A 411
VAL A 490
LEU A 492
VAL A 568
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.00A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 443
ASN A 464
ASP A 531
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
 0.03A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASN A 376
GLY A 379
LYS A 381
ASP A 443
VAL A 490
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.45A 5vopB-5vopA:
46.9		 5vopB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 GLU A 373
ASN A 376
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.48A 5vopB-5vopA:
46.9		 5vopB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 443
ASN A 464
ASP A 531
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
 0.13A 5vopB-5vopA:
46.9		 5vopB-5vopA:
undetectable