SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		3 / 3 ASP A   4
TYR A  11
LYS A  22
 None
 1.20A 2othA-5vp3A:
undetectable		 2othA-5vp3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 11 TYR A 131
LEU A 127
VAL A  81
PHE A  43
PHE A 155
 None
 1.44A 4evrA-5vp3A:
undetectable		 4evrA-5vp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 11 ASP A 170
ASP A 140
ASP A 136
GLY A 141
TYR A 132
 CD  A 203 (-3.1A)
CD  A 202 (-2.7A)
CD  A 202 ( 3.1A)
None
None
 1.42A 4lxzB-5vp3A:
undetectable		 4lxzB-5vp3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 9 PHE A 166
ALA A 162
PHE A 165
LEU A 177
VAL A 143
 None
None
None
None
CD  A 202 ( 4.9A)
 1.49A 4z69A-5vp3A:
undetectable		 4z69A-5vp3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		3 / 3 LEU A 126
LEU A 127
TRP A 190
 None
 0.90A 5nwuA-5vp3A:
undetectable		 5nwuA-5vp3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 11 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.39A 6mb5A-5vp3A:
undetectable		 6mb5A-5vp3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 10 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.38A 6mb9A-5vp3A:
undetectable		 6mb9A-5vp3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 10 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.44A 6mb9B-5vp3A:
undetectable		 6mb9B-5vp3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 10 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.41A 6mb9C-5vp3A:
undetectable		 6mb9C-5vp3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 5vp3 MNEMIOPSIN 1
(Mnemiopsis
leidyi) 		5 / 10 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.42A 6mb9D-5vp3A:
undetectable		 6mb9D-5vp3A:
24.44