SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 7 SER A 381
ALA A 383
TYR A 385
ALA A  29
 None
 0.85A 1k5qA-5vprA:
undetectable
1k5qB-5vprA:
undetectable		 1k5qA-5vprA:
20.29
1k5qB-5vprA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 5 ILE A 196
ILE A  79
ILE A 181
LEU A 242
 None
 0.94A 1zgyA-5vprA:
undetectable		 1zgyA-5vprA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 5 GLN A 170
ALA A 203
ILE A 209
ARG A 297
 None
 1.31A 2z0aA-5vprA:
undetectable		 2z0aA-5vprA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A  92
VAL A  38
GLY A 281
ASN A 278
ILE A 285
 LLP  A 225 ( 3.8A)
None
None
None
None
 1.28A 3k13A-5vprA:
undetectable		 3k13A-5vprA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A  92
VAL A  38
GLY A 281
ASN A 278
ILE A 285
 LLP  A 225 ( 3.8A)
None
None
None
None
 1.28A 3k13C-5vprA:
undetectable		 3k13C-5vprA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 6 TYR A 385
GLN A  10
ILE A   7
SER A  32
 None
None
None
LLP  A 225 ( 3.3A)
 1.10A 3peoG-5vprA:
undetectable		 3peoG-5vprA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 GLN A  10
ASP A   3
GLN A   5
 None
 0.84A 4aztA-5vprA:
undetectable		 4aztA-5vprA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A 176
THR A 149
ALA A 203
ALA A  29
VAL A 333
 None
 1.19A 4df3A-5vprA:
3.6		 4df3A-5vprA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A 176
THR A 149
ALA A 203
ALA A  29
VAL A 333
 None
 1.20A 4df3B-5vprA:
2.6		 4df3B-5vprA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 PHE A 336
PHE A 382
GLN A 312
ALA A 311
LEU A 351
 None
 1.11A 4j6dB-5vprA:
undetectable		 4j6dB-5vprA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		6 / 11 ASP A 199
GLY A 200
ALA A 201
THR A 232
GLY A 233
ILE A 234
 LLP  A 225 ( 2.7A)
None
LLP  A 225 ( 3.6A)
None
None
None
 1.34A 4qgiA-5vprA:
undetectable		 4qgiA-5vprA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  54
THR A  65
SER A  61
GLY A 275
PRO A 277
 None
 1.46A 4uinH-5vprA:
undetectable
4uinL-5vprA:
undetectable		 4uinH-5vprA:
18.61
4uinL-5vprA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 THR A 377
SER A 335
ASP A  27
 None
 0.85A 5kvaB-5vprA:
undetectable		 5kvaB-5vprA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A  34
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 4.9A)
 1.01A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A 226
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 3.5A)
 1.05A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 6 PRO A 180
VAL A 168
VAL A 166
ILE A 152
 None
 0.92A 5pbeA-5vprA:
undetectable		 5pbeA-5vprA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 ILE A 177
ILE A 181
SER A 172
THR A 149
LEU A 150
 None
 0.72A 5twjA-5vprA:
undetectable		 5twjA-5vprA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A  34
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 4.9A)
 1.01A 6gmdB-5vprA:
undetectable		 6gmdB-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A 226
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 3.5A)
 1.05A 6gmdB-5vprA:
undetectable		 6gmdB-5vprA:
22.25