SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 11 ALA A 254
ASP A 187
LEU A 222
GLY A 223
ALA A 192
 None
 1.08A 1b02A-5vpsA:
undetectable		 1b02A-5vpsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		3 / 3 TRP A 248
LEU A 182
LYS A 144
 None
 1.43A 1yajK-5vpsA:
2.6		 1yajK-5vpsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		3 / 3 TRP A 248
LEU A 249
LYS A 144
 None
 1.03A 1yajK-5vpsA:
2.6		 1yajK-5vpsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 10 ALA A  28
ILE A  51
CYH A  23
GLY A  22
CYH A 232
 None
 1.38A 2b17A-5vpsA:
undetectable		 2b17A-5vpsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 11 GLY A  22
ILE A  51
VAL A  59
LEU A  34
VAL A  12
 None
 0.97A 2kawA-5vpsA:
undetectable		 2kawA-5vpsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 12 GLY A 245
GLY A 166
LEU A 167
CYH A 236
ALA A 165
 None
 1.02A 3av6A-5vpsA:
4.4		 3av6A-5vpsA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 9 LEU A  34
GLY A  20
ALA A  15
VAL A  59
ILE A  36
 None
 0.95A 3oxvA-5vpsA:
undetectable		 3oxvA-5vpsA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		4 / 8 ALA A 165
GLY A 162
THR A 161
ARG A 169
 None
 0.95A 3rglA-5vpsA:
undetectable		 3rglA-5vpsA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		5 / 11 ALA A 231
VAL A 176
ILE A 178
ASN A 179
ILE A 120
 None
 1.24A 5y80A-5vpsA:
undetectable		 5y80A-5vpsA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
ambifaria) 		4 / 8 ASN A 137
VAL A 164
LEU A 167
ILE A 178
 None
 0.90A 6cb4A-5vpsA:
undetectable		 6cb4A-5vpsA:
22.72