SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 9 THR A  14
GLY A 189
GLY A  19
LEU A  17
ARG A 190
 None
 1.21A 1jhoA-5vq5A:
undetectable		 1jhoA-5vq5A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 9 THR A  14
GLY A 189
GLY A  19
LEU A  17
ARG A 190
 None
 1.22A 1jhrA-5vq5A:
undetectable		 1jhrA-5vq5A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 9 THR A  14
GLY A 189
GLY A  19
LEU A  17
ARG A 190
 None
 1.22A 1l5lA-5vq5A:
undetectable		 1l5lA-5vq5A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 9 THR A  14
GLY A 189
GLY A  19
LEU A  17
ARG A 190
 None
 1.21A 1l5mA-5vq5A:
undetectable		 1l5mA-5vq5A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 12 ILE A  95
GLY A  94
ILE A  68
VAL A  90
SER A  91
 None
 0.75A 1sg9B-5vq5A:
undetectable		 1sg9B-5vq5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 11 ILE A  97
GLY A  39
THR A  40
LEU A 186
GLY A  98
 None
 1.30A 2fn1A-5vq5A:
undetectable		 2fn1A-5vq5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 9 PHE A 137
ASP A   3
LEU A 175
PHE A  46
THR A 134
 None
None
None
None
IOD  A 306 ( 4.2A)
 1.27A 2tsrD-5vq5A:
undetectable		 2tsrD-5vq5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 11 SER A  67
ILE A  68
VAL A 146
VAL A  33
ILE A  95
 None
 0.96A 3rf4A-5vq5A:
undetectable
3rf4C-5vq5A:
undetectable		 3rf4A-5vq5A:
22.05
3rf4C-5vq5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 11 ILE A  95
SER A  67
ILE A  68
VAL A 146
VAL A  33
 None
 0.91A 3rf4A-5vq5A:
undetectable
3rf4B-5vq5A:
undetectable		 3rf4A-5vq5A:
22.05
3rf4B-5vq5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vq5 ADHESIN
(Escherichia
coli) 		5 / 11 ILE A  95
SER A  67
ILE A  68
VAL A 146
VAL A  33
 None
 0.91A 3rf4B-5vq5A:
undetectable
3rf4C-5vq5A:
undetectable		 3rf4B-5vq5A:
22.05
3rf4C-5vq5A:
22.05