SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.23A 2eimJ-5vqhA:
undetectable		 2eimJ-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.22A 2eimW-5vqhA:
undetectable		 2eimW-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 10 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.95A 2f16K-5vqhA:
undetectable
2f16L-5vqhA:
undetectable		 2f16K-5vqhA:
22.43
2f16L-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 10 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.96A 2f16Y-5vqhA:
undetectable
2f16Z-5vqhA:
undetectable		 2f16Y-5vqhA:
22.43
2f16Z-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 11 GLN A  19
ILE A 192
PHE A  20
PHE A  16
LEU A 194
 None
 1.21A 2q6hA-5vqhA:
undetectable		 2q6hA-5vqhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 11 GLN A  19
ILE A 192
PHE A  20
PHE A  16
LEU A 194
 None
 1.21A 2qeiA-5vqhA:
undetectable		 2qeiA-5vqhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 11 GLN A  19
ILE A 192
PHE A  20
PHE A  16
LEU A 194
 None
 1.15A 2qjuA-5vqhA:
undetectable		 2qjuA-5vqhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.28A 3ag1J-5vqhA:
undetectable		 3ag1J-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 11 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.96A 3mg0K-5vqhA:
undetectable
3mg0L-5vqhA:
undetectable		 3mg0K-5vqhA:
22.43
3mg0L-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 8 TRP A  69
TYR A  93
ARG A  68
MET A  35
 None
2MR  A 501 (-3.9A)
2MR  A 501 (-4.4A)
None
 1.38A 3wipB-5vqhA:
undetectable
3wipC-5vqhA:
undetectable		 3wipB-5vqhA:
22.56
3wipC-5vqhA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 9 LEU A 126
VAL A  18
CYH A 124
GLY A 191
THR A 174
 None
 1.42A 5w5vA-5vqhA:
undetectable		 5w5vA-5vqhA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.10A 5w97J-5vqhA:
undetectable		 5w97J-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.27A 5wauJ-5vqhA:
undetectable		 5wauJ-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 4 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.38A 5x19W-5vqhA:
0.0		 5x19W-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 5 TYR A  39
ARG A  45
THR A  49
LEU A  50
 None
 1.27A 5z86J-5vqhA:
undetectable		 5z86J-5vqhA:
11.81