SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 11 LEU B 337
ILE B 359
ILE B 379
ILE B 370
THR B 328
 None
 1.07A 1dyrA-5vqiB:
undetectable		 1dyrA-5vqiB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 5 TYR B 277
PRO B 244
LEU B 205
THR B 230
 None
 1.33A 1i2wA-5vqiB:
undetectable		 1i2wA-5vqiB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 8 LEU B 427
SER B 402
SER B 406
GLN B 414
 None
 1.01A 1ig3A-5vqiB:
undetectable
1ig3B-5vqiB:
undetectable		 1ig3A-5vqiB:
21.66
1ig3B-5vqiB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 7 GLN B 414
LEU B 427
SER B 402
SER B 406
 None
 1.07A 1ig3A-5vqiB:
undetectable
1ig3B-5vqiB:
undetectable		 1ig3A-5vqiB:
21.66
1ig3B-5vqiB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 12 LEU B 216
ALA B 144
ALA B 147
ALA B 145
LEU B 190
 None
 1.36A 1rbpA-5vqiB:
undetectable		 1rbpA-5vqiB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 12 LEU B 302
LEU B 314
ILE B 359
LEU B 344
LEU B 341
 None
 1.05A 2bdmA-5vqiB:
undetectable		 2bdmA-5vqiB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 10 THR B 328
ILE B 331
GLY B 323
PRO B 295
ILE B 286
 None
 1.40A 2y7wB-5vqiB:
undetectable		 2y7wB-5vqiB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 5 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.17A 3bjwA-5vqiB:
undetectable		 3bjwA-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 5 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.22A 3bjwG-5vqiB:
undetectable		 3bjwG-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 5 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.22A 3bjwC-5vqiB:
undetectable		 3bjwC-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 5 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.15A 3bjwD-5vqiB:
undetectable		 3bjwD-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 10 LEU B 431
ALA B 498
ILE B 501
LEU B 450
PHE B 506
 None
 1.23A 3fl9F-5vqiB:
undetectable		 3fl9F-5vqiB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 8 ALA B 376
ILE B 378
ASN B 377
PRO B 381
 None
 0.99A 3fxrA-5vqiB:
undetectable		 3fxrA-5vqiB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		3 / 3 ARG B 315
GLU B 396
ASP B 435
 None
 0.74A 3g2oA-5vqiB:
undetectable		 3g2oA-5vqiB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 8 ILE B 351
GLN B 310
ALA B 313
LEU B 314
 None
 0.62A 3ozwA-5vqiB:
undetectable		 3ozwA-5vqiB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 12 ILE B 351
HIS B 304
GLN B 310
ALA B 313
LEU B 314
 None
 0.97A 3ozwB-5vqiB:
undetectable		 3ozwB-5vqiB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		3 / 3 TRP B 188
TRP B 231
THR B 232
 None
 1.40A 4bboB-5vqiB:
undetectable		 4bboB-5vqiB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 12 ILE B 269
ILE B 249
ALA B 252
LEU B 256
ALA B 257
 None
 1.21A 5oy02-5vqiB:
undetectable		 5oy02-5vqiB:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 12 SER B 220
ALA B 229
THR B 232
ALA B 186
GLU B 179
 None
 1.20A 5vcgA-5vqiB:
undetectable		 5vcgA-5vqiB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		5 / 10 ILE B 269
ILE B 249
ALA B 252
LEU B 256
ALA B 257
 None
 1.22A 5zjiB-5vqiB:
1.9		 5zjiB-5vqiB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5vqi IMPORTIN SUBUNIT
ALPHA
(Neurospora
crassa) 		4 / 6 SER B 220
ALA B 229
THR B 232
ALA B 186
 None
 1.09A 6ma6A-5vqiB:
undetectable		 6ma6A-5vqiB:
8.99