SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 8 GLU A 321
ARG A 324
ARG A 325
GLU A 133
 None
 0.96A 1cmaA-5vrbA:
undetectable
1cmaB-5vrbA:
undetectable		 1cmaA-5vrbA:
10.65
1cmaB-5vrbA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 ASN A 135
ALA A 131
ASP A 143
GLU A 127
 None
 1.25A 1lqtA-5vrbA:
2.9
1lqtB-5vrbA:
undetectable		 1lqtA-5vrbA:
21.91
1lqtB-5vrbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 ASN A 135
ALA A 131
ASP A 143
GLU A 127
 None
 1.24A 1lquA-5vrbA:
undetectable
1lquB-5vrbA:
undetectable		 1lquA-5vrbA:
21.91
1lquB-5vrbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 451
HIS A 509
SER A 511
VAL A 453
 None
 1.23A 1u1jA-5vrbA:
undetectable		 1u1jA-5vrbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 VAL A 651
ASN A 650
VAL A 607
ILE A 605
 None
 0.87A 1z2bC-5vrbA:
undetectable		 1z2bC-5vrbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 PRO A 426
GLY A 417
ASN A 416
GLY A 412
 None
 1.09A 1zlqA-5vrbA:
undetectable		 1zlqA-5vrbA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 11 ARG A 355
ILE A 362
LEU A 372
TYR A 401
GLY A 428
 None
 0.98A 2bxmA-5vrbA:
undetectable		 2bxmA-5vrbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 104
TYR A  77
LYS A 294
 None
 1.18A 2othA-5vrbA:
undetectable		 2othA-5vrbA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 ALA A 313
TYR A 315
ALA A 309
TYR A 311
 None
 1.19A 2wlkA-5vrbA:
undetectable
2wlkB-5vrbA:
undetectable		 2wlkA-5vrbA:
19.16
2wlkB-5vrbA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 11 ALA A  34
GLY A  29
GLY A 215
ILE A 221
HIS A 216
 None
 1.13A 2x1lA-5vrbA:
undetectable		 2x1lA-5vrbA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 TYR A  77
LEU A  79
LEU A  72
HIS A  44
 None
 1.12A 2x7hB-5vrbA:
2.0		 2x7hB-5vrbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 418
ALA A 126
ALA A 124
VAL A 148
THR A 146
 None
 1.25A 3cwkA-5vrbA:
undetectable		 3cwkA-5vrbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 10 ASN A  61
LEU A  59
GLY A  62
HIS A  63
PHE A  87
 OCS  A 154 ( 4.3A)
None
None
CA  A 704 ( 4.9A)
None
 1.26A 3h9uB-5vrbA:
2.6		 3h9uB-5vrbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 515
ALA A 429
THR A 385
ILE A 362
ILE A 364
 None
 1.31A 3ld6A-5vrbA:
undetectable		 3ld6A-5vrbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 305
GLN A 310
PHE A 308
ASN A  53
 None
 1.28A 3n62A-5vrbA:
undetectable		 3n62A-5vrbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 305
GLN A 310
PHE A 308
ASN A  53
 None
 1.31A 3n62B-5vrbA:
undetectable		 3n62B-5vrbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 THR A 430
PHE A 431
ARG A 355
LEU A 384
 None
 1.10A 3qelC-5vrbA:
4.1		 3qelC-5vrbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 SER A 392
GLY A 405
GLU A 438
GLU A 408
 None
 1.48A 3raeB-5vrbA:
undetectable
3raeD-5vrbA:
4.4		 3raeB-5vrbA:
20.44
3raeD-5vrbA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 PRO A 235
ILE A 117
LEU A 166
ILE A 414
ALA A 413
 None
 1.03A 3vrmA-5vrbA:
undetectable		 3vrmA-5vrbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 ALA A 224
GLY A 215
CYH A 240
LYS A 241
 None
 1.49A 3zwiA-5vrbA:
undetectable		 3zwiA-5vrbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 489
THR A 612
TRP A 615
 None
 1.28A 4d7hA-5vrbA:
undetectable		 4d7hA-5vrbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 513
ILE A 362
ALA A 429
PHE A 427
 None
 1.00A 4dc3B-5vrbA:
undetectable		 4dc3B-5vrbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLY A 410
GLY A 412
ASN A 416
GLU A 162
 None
 1.28A 4fglC-5vrbA:
3.8		 4fglC-5vrbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 9 PRO A 426
VAL A 373
TYR A 401
SER A 376
GLY A 428
 None
 1.24A 4mm5A-5vrbA:
undetectable		 4mm5A-5vrbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 11 PRO A 426
VAL A 373
TYR A 401
SER A 376
GLY A 428
 None
 1.18A 4mmaA-5vrbA:
undetectable		 4mmaA-5vrbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 10 TYR A 404
PRO A 426
VAL A 373
TYR A 401
GLY A 428
 None
 1.35A 4mmdA-5vrbA:
undetectable		 4mmdA-5vrbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_2
(ANDROGEN RECEPTOR)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 ASN A  86
MET A  66
LEU A  79
HIS A  73
 None
 1.27A 4oktA-5vrbA:
0.0		 4oktA-5vrbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 602
VAL A 655
LEU A 659
ILE A 605
ALA A 547
 None
 1.02A 4p65F-5vrbA:
undetectable
4p65H-5vrbA:
undetectable
4p65K-5vrbA:
undetectable
4p65L-5vrbA:
undetectable		 4p65F-5vrbA:
4.40
4p65H-5vrbA:
4.40
4p65K-5vrbA:
3.09
4p65L-5vrbA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 489
THR A 612
TRP A 615
 None
 1.28A 4ug5A-5vrbA:
undetectable		 4ug5A-5vrbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 489
THR A 612
TRP A 615
 None
 1.20A 4uglA-5vrbA:
0.0		 4uglA-5vrbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 SER A 516
GLU A 557
GLN A 523
GLY A 559
LEU A 520
 None
EDO  A 701 (-3.8A)
None
None
None
 1.27A 4uilH-5vrbA:
undetectable
4uilL-5vrbA:
undetectable		 4uilH-5vrbA:
15.35
4uilL-5vrbA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 362
LEU A 372
TYR A 401
GLY A 428
 None
 0.90A 4z69A-5vrbA:
undetectable		 4z69A-5vrbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 489
THR A 612
TRP A 615
 None
 1.28A 5g6cA-5vrbA:
undetectable		 5g6cA-5vrbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8A-5vrbA:
2.8		 5hm8A-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8B-5vrbA:
2.8		 5hm8B-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8C-5vrbA:
2.8		 5hm8C-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.20A 5hm8D-5vrbA:
2.7		 5hm8D-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8E-5vrbA:
undetectable		 5hm8E-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.20A 5hm8F-5vrbA:
undetectable		 5hm8F-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8G-5vrbA:
undetectable		 5hm8G-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8H-5vrbA:
undetectable		 5hm8H-5vrbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 10 ALA A 357
THR A 493
SER A 496
ALA A 353
SER A 516
 None
 1.18A 5l66K-5vrbA:
undetectable
5l66L-5vrbA:
undetectable		 5l66K-5vrbA:
15.21
5l66L-5vrbA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 10 ALA A 357
THR A 493
SER A 496
ALA A 353
SER A 516
 None
 1.17A 5l66Y-5vrbA:
undetectable
5l66Z-5vrbA:
undetectable		 5l66Y-5vrbA:
15.21
5l66Z-5vrbA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.27A 5v96A-5vrbA:
2.5		 5v96A-5vrbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.25A 5v96B-5vrbA:
undetectable		 5v96B-5vrbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		4 / 4 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.26A 5v96D-5vrbA:
2.6		 5v96D-5vrbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 ASN A  61
LEU A  59
GLY A  62
HIS A  63
PHE A  87
 OCS  A 154 ( 4.3A)
None
None
CA  A 704 ( 4.9A)
None
 1.26A 6exiA-5vrbA:
undetectable		 6exiA-5vrbA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5vrb TRANSKETOLASE
(Neisseria
gonorrhoeae) 		5 / 12 ASN A  61
LEU A  59
GLY A  62
HIS A  63
PHE A  87
 OCS  A 154 ( 4.3A)
None
None
CA  A 704 ( 4.9A)
None
 1.29A 6exiD-5vrbA:
undetectable		 6exiD-5vrbA:
9.04