SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 12 TYR A  64
ILE A  68
ARG A  91
HIS A  41
ARG A  61
 None
 1.22A 1tw4B-5vrcA:
undetectable		 1tw4B-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 12 ALA A  56
GLN A 252
PRO A 247
GLY A 244
LEU A 236
 None
 1.17A 2nv4A-5vrcA:
undetectable		 2nv4A-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 12 ALA A  56
GLN A 252
PRO A 247
GLY A 244
LEU A 236
 None
 1.30A 2nv4B-5vrcA:
undetectable		 2nv4B-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		4 / 5 TYR A 176
VAL A  54
ARG A  61
HIS A  41
 None
 1.31A 3zofA-5vrcA:
undetectable		 3zofA-5vrcA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		4 / 5 TYR A 176
VAL A  54
ARG A  61
HIS A  41
 None
 1.37A 3zofB-5vrcA:
undetectable		 3zofB-5vrcA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 12 ALA A  58
LEU A  59
ALA A  56
PHE A  40
LEU A  49
 None
 1.20A 5k9dA-5vrcA:
undetectable		 5k9dA-5vrcA:
undetectable