SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.23A 1a52A-5vrdD:
undetectable		 1a52A-5vrdD:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.25A 1a52B-5vrdD:
2.0		 1a52B-5vrdD:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 9 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.28A 1ereA-5vrdD:
undetectable		 1ereA-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 9 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.29A 1ereB-5vrdD:
1.8		 1ereB-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 9 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.29A 1ereC-5vrdD:
2.1		 1ereC-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 9 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.29A 1ereD-5vrdD:
2.0		 1ereD-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ARG D  91
SER D 155
LEU D 156
ALA D 201
LEU D 202
 None
 1.36A 1hwkB-5vrdD:
undetectable		 1hwkB-5vrdD:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ARG D  91
SER D 155
LEU D 156
ALA D 201
LEU D 202
 None
 1.37A 1hwkA-5vrdD:
undetectable		 1hwkA-5vrdD:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ARG D  91
SER D 155
LEU D 156
ALA D 201
LEU D 202
 None
 1.37A 1hwkD-5vrdD:
undetectable		 1hwkD-5vrdD:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ARG D  91
SER D 155
LEU D 156
ALA D 201
LEU D 202
 None
 1.37A 1hwkC-5vrdD:
undetectable		 1hwkC-5vrdD:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 1pcgA-5vrdD:
2.1		 1pcgA-5vrdD:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.25A 1pcgB-5vrdD:
2.1		 1pcgB-5vrdD:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.19A 1qkuA-5vrdD:
undetectable		 1qkuA-5vrdD:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.19A 1qkuB-5vrdD:
undetectable		 1qkuB-5vrdD:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.19A 1qkuC-5vrdD:
undetectable		 1qkuC-5vrdD:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.33A 2ocfA-5vrdD:
1.7		 2ocfA-5vrdD:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 12 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 3olsB-5vrdD:
undetectable		 3olsB-5vrdD:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.25A 3uudA-5vrdD:
undetectable		 3uudA-5vrdD:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.23A 3uudB-5vrdD:
2.0		 3uudB-5vrdD:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		4 / 7 ALA D 153
ALA D 209
ALA D 217
LEU D 149
 None
 0.88A 4du2B-5vrdD:
undetectable		 4du2B-5vrdD:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		4 / 6 ASP D  94
ASP D  72
ARG D  91
GLU D 158
 None
 1.04A 4eysA-5vrdD:
undetectable		 4eysA-5vrdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		3 / 3 LEU D  84
ARG D  86
ARG D  85
 None
 0.90A 4yiaB-5vrdD:
undetectable		 4yiaB-5vrdD:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 5dxeB-5vrdD:
undetectable		 5dxeB-5vrdD:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.25A 5dxgB-5vrdD:
undetectable		 5dxgB-5vrdD:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.24A 5hyrA-5vrdD:
undetectable		 5hyrA-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 11 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.28A 5hyrB-5vrdD:
undetectable		 5hyrB-5vrdD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D
(Methylobacterium
extorquens) 		5 / 10 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 6cbzB-5vrdD:
undetectable		 6cbzB-5vrdD:
20.24