SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 7 LEU B 168
ALA B 180
SER B  44
SER B  40
 None
 1.03A 1dvxA-5vrfB:
undetectable		 1dvxA-5vrfB:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		5 / 12 LEU B  83
GLY B  78
TYR B  64
HIS B  73
HIS B  77
 None
None
None
ZN  B 302 (-3.2A)
ZN  B 302 (-3.4A)
 1.43A 1s9aB-5vrfB:
undetectable		 1s9aB-5vrfB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		5 / 12 LEU B 118
ALA B  32
LEU B  31
VAL B 125
ALA B 126
 None
 1.14A 1sa1A-5vrfB:
undetectable
1sa1B-5vrfB:
undetectable		 1sa1A-5vrfB:
10.93
1sa1B-5vrfB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		5 / 12 LEU B 118
ALA B  32
LEU B  31
VAL B 125
ALA B 126
 None
 1.18A 1sa1C-5vrfB:
undetectable
1sa1D-5vrfB:
undetectable		 1sa1C-5vrfB:
10.93
1sa1D-5vrfB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 7 ALA B  22
THR B  21
ALA B  20
ARG B  16
 None
 0.86A 2ql8A-5vrfB:
3.7
2ql8B-5vrfB:
3.8		 2ql8A-5vrfB:
undetectable
2ql8B-5vrfB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 8 ASP B  47
ILE B 192
HIS B 155
ASP B 159
 ZN  B 301 (-2.1A)
None
ZN  B 301 (-3.2A)
ZN  B 301 (-2.3A)
 1.00A 2xadA-5vrfB:
undetectable		 2xadA-5vrfB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 8 ASP B  47
ILE B 192
HIS B 155
ASP B 159
 ZN  B 301 (-2.1A)
None
ZN  B 301 (-3.2A)
ZN  B 301 (-2.3A)
 1.03A 2xadB-5vrfB:
undetectable		 2xadB-5vrfB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 8 ASP B  47
ILE B 192
HIS B 155
ASP B 159
 ZN  B 301 (-2.1A)
None
ZN  B 301 (-3.2A)
ZN  B 301 (-2.3A)
 1.01A 2xadC-5vrfB:
undetectable		 2xadC-5vrfB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 8 ASP B  47
ILE B 192
HIS B 155
ASP B 159
 ZN  B 301 (-2.1A)
None
ZN  B 301 (-3.2A)
ZN  B 301 (-2.3A)
 1.03A 2xadD-5vrfB:
undetectable		 2xadD-5vrfB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 6 ASP B  47
HIS B 155
TYR B 156
ASN B  58
 ZN  B 301 (-2.1A)
ZN  B 301 (-3.2A)
None
None
 1.40A 2zs9A-5vrfB:
undetectable		 2zs9A-5vrfB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 5 VAL B 166
LEU B 167
ILE B 127
ALA B 126
 None
 0.96A 3n8yB-5vrfB:
undetectable		 3n8yB-5vrfB:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		3 / 4 ARG B 106
GLY B 104
GLU B 105
 None
 0.67A 4z2dB-5vrfB:
1.3
4z2dC-5vrfB:
undetectable		 4z2dB-5vrfB:
9.22
4z2dC-5vrfB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 5 GLY B 182
ARG B 106
GLY B 104
GLU B 105
 None
 1.02A 4z2eB-5vrfB:
1.4
4z2eC-5vrfB:
undetectable		 4z2eB-5vrfB:
9.22
4z2eC-5vrfB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 7 GLY B 182
ASP B 181
GLY B 103
GLU B 105
 None
 0.93A 4z53A-5vrfB:
undetectable
4z53B-5vrfB:
undetectable		 4z53A-5vrfB:
7.90
4z53B-5vrfB:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		5 / 6 SER B  95
GLY B 182
ASP B 181
ARG B 106
GLY B 104
 None
 1.34A 5cdnC-5vrfB:
5.5
5cdnD-5vrfB:
undetectable		 5cdnC-5vrfB:
9.93
5cdnD-5vrfB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 6 GLY B 182
ASP B 181
ARG B 106
GLY B 104
 None
 0.97A 5cdpA-5vrfB:
undetectable
5cdpB-5vrfB:
undetectable		 5cdpA-5vrfB:
9.91
5cdpB-5vrfB:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		4 / 7 ALA B 262
THR B 266
ILE B 284
LEU B 251
 None
 1.00A 5te8A-5vrfB:
undetectable		 5te8A-5vrfB:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF
(Shewanella
oneidensis) 		3 / 3 HIS B 285
HIS B 250
ARG B 237
 ZN  B 303 (-3.5A)
ZN  B 304 (-3.0A)
None
 0.98A 6b58A-5vrfB:
4.6		 6b58A-5vrfB:
undetectable