SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ARG A 176
ILE A 173
ALA A 175
LEU A 170
VAL A 129
 None
 1.20A 3o01A-5vrqA:
undetectable
3o01B-5vrqA:
undetectable		 3o01A-5vrqA:
undetectable
3o01B-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 10 ARG A 176
ILE A 173
ALA A 175
LEU A 170
VAL A 129
 None
 1.17A 3o02A-5vrqA:
undetectable
3o02B-5vrqA:
undetectable		 3o02A-5vrqA:
15.33
3o02B-5vrqA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 271
ALA A 234
LEU A 242
ILE A 231
 None
 0.79A 4ubsA-5vrqA:
undetectable		 4ubsA-5vrqA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 10 ALA A 101
LEU A 169
ALA A 172
LEU A 160
ALA A 161
 None
 1.15A 4zbrA-5vrqA:
undetectable		 4zbrA-5vrqA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 160
GLY A  96
ASP A 151
LEU A  89
ALA A 101
 None
 0.98A 5l0zA-5vrqA:
undetectable		 5l0zA-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 9 ILE A 363
ILE A 297
ILE A 293
LEU A 290
 None
 0.74A 5vkqB-5vrqA:
14.1
5vkqC-5vrqA:
14.0		 5vkqB-5vrqA:
undetectable
5vkqC-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 6 VAL A 339
LEU A 321
LEU A 366
HIS A 365
 None
 0.97A 6e43A-5vrqA:
undetectable		 6e43A-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 6 VAL A 339
LEU A 321
LEU A 366
HIS A 365
 None
 1.00A 6e43B-5vrqA:
undetectable		 6e43B-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 6 VAL A 339
LEU A 321
LEU A 366
HIS A 365
 None
 0.97A 6e43C-5vrqA:
undetectable		 6e43C-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 6 VAL A 339
LEU A 321
LEU A 366
HIS A 365
 None
 0.89A 6e43D-5vrqA:
undetectable		 6e43D-5vrqA:
undetectable