SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		3 / 3 ARG A 611
VAL A 603
TRP A 604
 None
 1.09A 1qw6A-5vrvA:
undetectable		 1qw6A-5vrvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		3 / 3 ARG A 611
VAL A 603
TRP A 604
 None
 1.10A 1vagA-5vrvA:
undetectable		 1vagA-5vrvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		3 / 3 ARG A 611
VAL A 603
TRP A 604
 None
 1.07A 1zviA-5vrvA:
undetectable		 1zviA-5vrvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 7 SER A 720
ARG A 561
LEU A 559
THR A 546
 None
 1.15A 2f78A-5vrvA:
undetectable		 2f78A-5vrvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 7 SER A 720
ARG A 561
LEU A 559
THR A 546
 None
 1.08A 2f78B-5vrvA:
undetectable		 2f78B-5vrvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		5 / 9 LEU A 626
ILE A 577
ALA A 588
GLY A 634
LEU A 635
 None
 1.05A 2v0mB-5vrvA:
undetectable		 2v0mB-5vrvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		5 / 9 SER A 709
ILE A 856
ALA A 852
GLY A 641
LEU A 640
 None
 1.05A 2v0mB-5vrvA:
undetectable		 2v0mB-5vrvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 7 TYR A 816
LEU A 710
TYR A 620
LYS A 565
 None
 1.36A 2w98A-5vrvA:
undetectable
2w98B-5vrvA:
undetectable		 2w98A-5vrvA:
21.78
2w98B-5vrvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 7 ASP A 632
SER A 628
GLU A 596
ASP A 595
 None
 1.20A 3bc9A-5vrvA:
undetectable		 3bc9A-5vrvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 4 ILE A 548
GLN A 552
VAL A 549
PHE A 576
 None
 1.06A 3ieoA-5vrvA:
undetectable		 3ieoA-5vrvA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		5 / 12 ILE A 587
ALA A 846
GLY A 812
ALA A 852
THR A 853
 None
 1.16A 4enhA-5vrvA:
undetectable		 4enhA-5vrvA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 6 SER A 755
GLY A 668
ASP A 671
GLY A 761
 None
 1.04A 4koeA-5vrvA:
undetectable
4koeB-5vrvA:
undetectable
4koeC-5vrvA:
undetectable		 4koeA-5vrvA:
23.03
4koeB-5vrvA:
23.03
4koeC-5vrvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 5 GLY A 696
ASP A 695
GLU A 689
VAL A 683
 None
 1.17A 4nkvD-5vrvA:
undetectable		 4nkvD-5vrvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		5 / 9 VAL A 839
ARG A 616
ALA A 852
VAL A 854
ASP A 851
 None
 1.24A 6c2mA-5vrvA:
undetectable		 6c2mA-5vrvA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5vrv PROTEIN REGULATED BY
ACID PH
(Agrobacterium
fabrum) 		4 / 6 HIS A 811
TYR A 816
TYR A 620
GLN A 621
 None
 1.13A 6d8pA-5vrvA:
0.2		 6d8pA-5vrvA:
18.59