SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vsd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
4 / 8 SER A1196
PHE A1226
ILE A1187
ASN A1194
None
0.85A 1pnlA-5vsdA:
undetectable
1pnlB-5vsdA:
undetectable
1pnlA-5vsdA:
19.07
1pnlB-5vsdA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
4 / 7 ALA A1189
TYR A1173
ARG A1190
PHE A1198
None
SAM  A3001 (-4.0A)
None
None
1.18A 2ajvH-5vsdA:
undetectable
2ajvL-5vsdA:
undetectable
2ajvH-5vsdA:
15.33
2ajvL-5vsdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 10 GLY A1137
SER A1172
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.52A 2h21A-5vsdA:
7.2
2h21A-5vsdA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
SER A1172
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.59A 2h21B-5vsdA:
7.0
2h21B-5vsdA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
SER A1172
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.55A 2h21C-5vsdA:
6.7
2h21C-5vsdA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
3 / 3 ASN A1122
ARG A1125
ASP A1085
None
0.97A 2qe6B-5vsdA:
undetectable
2qe6B-5vsdA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.41A 2r3aA-5vsdA:
28.2
2r3aA-5vsdA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 ILE A1146
ALA A1234
ILE A1021
PRO A1022
LEU A1124
None
1.17A 2w3bB-5vsdA:
undetectable
2w3bB-5vsdA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
4 / 5 GLY A1193
ARG A1197
TYR A1038
TYR A1040
None
1.46A 2wb9A-5vsdA:
undetectable
2wb9A-5vsdA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
8 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.43A 3ooiA-5vsdA:
19.6
3ooiA-5vsdA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.42A 3ooiA-5vsdA:
19.6
3ooiA-5vsdA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.42A 3ooiA-5vsdA:
19.6
3ooiA-5vsdA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.30A 3opeA-5vsdA:
18.1
3opeA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.47A 3opeA-5vsdA:
18.1
3opeA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 9 GLY A1137
TRP A1138
TYR A1173
ASN A1200
TYR A1242
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.8A)
0.46A 3opeB-5vsdA:
17.5
3opeB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.65A 3qxyA-5vsdA:
7.3
3qxyA-5vsdA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.62A 3rc0B-5vsdA:
7.2
3rc0B-5vsdA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.39A 3s8pA-5vsdA:
10.7
3s8pA-5vsdA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
3 / 3 ARG A1220
PHE A1221
PRO A1222
None
0.82A 3zoaB-5vsdA:
undetectable
3zoaB-5vsdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.40A 4bupA-5vsdA:
10.6
4bupA-5vsdA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.51A 4ynmA-5vsdA:
18.2
4ynmA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.24A 4ynmA-5vsdA:
18.2
4ynmA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.39A 4ynmB-5vsdA:
18.2
4ynmB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.38A 4ynmB-5vsdA:
18.2
4ynmB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.11A 4ynmB-5vsdA:
18.2
4ynmB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.55A 4ynpA-5vsdA:
18.1
4ynpA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.35A 4ynpA-5vsdA:
18.1
4ynpA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.03A 4ynpA-5vsdA:
18.1
4ynpA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.43A 4ynpA-5vsdA:
18.1
4ynpA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 10 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.42A 4ynpB-5vsdA:
18.0
4ynpB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 10 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.34A 4ynpB-5vsdA:
18.0
4ynpB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 10 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1256
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
1.49A 4ynpB-5vsdA:
18.0
4ynpB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 10 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.17A 4ynpB-5vsdA:
18.0
4ynpB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.47A 4ypaA-5vsdA:
18.7
4ypaA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.33A 4ypaA-5vsdA:
18.7
4ypaA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.31A 4ypaB-5vsdA:
18.4
4ypaB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.17A 4ypaB-5vsdA:
18.4
4ypaB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.46A 4ypaC-5vsdA:
18.9
4ypaC-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.20A 4ypaC-5vsdA:
18.9
4ypaC-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.38A 4ypaD-5vsdA:
18.5
4ypaD-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.29A 4ypaD-5vsdA:
18.5
4ypaD-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.26A 4ypeA-5vsdA:
18.9
4ypeA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.49A 4ypeA-5vsdA:
18.9
4ypeA-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.29A 4ypeB-5vsdA:
18.6
4ypeB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 11 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.25A 4ypeB-5vsdA:
18.6
4ypeB-5vsdA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.45A 4ypuA-5vsdA:
18.3
4ypuA-5vsdA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.38A 4ypuA-5vsdA:
18.3
4ypuA-5vsdA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.10A 4ypuA-5vsdA:
18.3
4ypuA-5vsdA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 11 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.52A 4ypuB-5vsdA:
17.8
4ypuB-5vsdA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 PHE A1198
HIS A1201
TYR A1242
CYH A1256
CYH A1258
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
1.36A 5cprB-5vsdA:
9.5
5cprB-5vsdA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.58A 5jhnA-5vsdA:
40.3
5jhnA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.49A 5jhnB-5vsdA:
40.0
5jhnB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.61A 5jinA-5vsdA:
40.4
5jinA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.62A 5jinB-5vsdA:
40.0
5jinB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.59A 5jiyA-5vsdA:
40.3
5jiyA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.60A 5jiyB-5vsdA:
39.8
5jiyB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.60A 5jj0A-5vsdA:
40.3
5jj0A-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.61A 5jj0B-5vsdA:
39.9
5jj0B-5vsdA:
77.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
ASN A1200
HIS A1201
TYR A1242
PHE A1246
SAM  A3001 (-3.6A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
0.66A 5kklB-5vsdA:
5.4
5kklB-5vsdA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.41A 5lsuA-5vsdA:
20.2
5lsuA-5vsdA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
ZN  A3005 (-2.3A)
0.43A 5lsuB-5vsdA:
19.9
5lsuB-5vsdA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
3 / 3 ASN A1200
TYR A1242
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.12A 5lsuB-5vsdA:
19.9
5lsuB-5vsdA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
PHE A1246
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
1.06A 5t0kA-5vsdA:
40.0
5t0kA-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.47A 5t0kA-5vsdA:
40.0
5t0kA-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.49A 5t0kA-5vsdA:
40.0
5t0kA-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.46A 5t0kB-5vsdA:
37.2
5t0kB-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
10 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.48A 5t0kB-5vsdA:
37.2
5t0kB-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
9 / 12 MET A1136
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.58A 5t0kB-5vsdA:
37.2
5t0kB-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.57A 5t0mA-5vsdA:
40.0
5t0mA-5vsdA:
77.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.50A 5t0mB-5vsdA:
40.4
5t0mB-5vsdA:
77.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 10 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.24A 5tegB-5vsdA:
13.8
5tegE-5vsdA:
undetectable
5tegB-5vsdA:
23.99
5tegE-5vsdA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 10 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
0.41A 5tqrB-5vsdA:
3.8
5tqrB-5vsdA:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 11 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.43A 5ttfA-5vsdA:
41.1
5ttfA-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 11 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.28A 5ttfA-5vsdA:
41.1
5ttfA-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.47A 5ttfB-5vsdA:
40.5
5ttfB-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.27A 5ttfB-5vsdA:
40.5
5ttfB-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
None
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.33A 5ttfC-5vsdA:
40.1
5ttfC-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 11 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.22A 5ttfD-5vsdA:
41.5
5ttfD-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 11 MET A1136
GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.49A 5ttfD-5vsdA:
41.5
5ttfD-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.41A 5ttgA-5vsdA:
43.1
5ttgA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.44A 5ttgA-5vsdA:
43.1
5ttgA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.10A 5ttgA-5vsdA:
43.1
5ttgA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
10 / 12 MET A1136
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.45A 5ttgA-5vsdA:
43.1
5ttgA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 11 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.42A 5ttgB-5vsdA:
43.6
5ttgB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.43A 5ttgB-5vsdA:
43.6
5ttgB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 11 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.11A 5ttgB-5vsdA:
43.6
5ttgB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.34A 5tuyA-5vsdA:
40.0
5tuyA-5vsdA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 MET A1136
GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.47A 5tuyA-5vsdA:
40.0
5tuyA-5vsdA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.38A 5tuyB-5vsdA:
39.6
5tuyB-5vsdA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 MET A1136
GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.48A 5tuyB-5vsdA:
39.6
5tuyB-5vsdA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
ZN  A3005 (-2.3A)
0.48A 5tuzA-5vsdA:
43.6
5tuzA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.43A 5tuzB-5vsdA:
43.3
5tuzB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 MET A1136
GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.45A 5tuzB-5vsdA:
43.3
5tuzB-5vsdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
1.46A 5updA-5vsdA:
19.8
5updA-5vsdA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
8 / 11 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.51A 5updA-5vsdA:
19.8
5updA-5vsdA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.47A 5updA-5vsdA:
19.8
5updA-5vsdA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
3 / 3 TYR A1038
ALA A1015
TYR A1040
None
0.84A 5uunB-5vsdA:
undetectable
5uunB-5vsdA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
0.54A 5v21A-5vsdA:
18.6
5v21A-5vsdA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.39A 5v21A-5vsdA:
18.6
5v21A-5vsdA:
28.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.43A 5v9iA-5vsdA:
40.8
5v9iA-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.23A 5v9iA-5vsdA:
40.8
5v9iA-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 11 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.46A 5v9iB-5vsdA:
40.8
5v9iB-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 11 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.25A 5v9iB-5vsdA:
40.8
5v9iB-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 11 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.22A 5v9iC-5vsdA:
41.1
5v9iC-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 11 MET A1136
GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.48A 5v9iC-5vsdA:
41.1
5v9iC-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
None
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.31A 5v9iD-5vsdA:
40.7
5v9iD-5vsdA:
76.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.40A 5v9jA-5vsdA:
43.0
5v9jA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.46A 5v9jA-5vsdA:
43.0
5v9jA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.39A 5v9jA-5vsdA:
43.0
5v9jA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.42A 5v9jB-5vsdA:
43.4
5v9jB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.43A 5v9jB-5vsdA:
43.4
5v9jB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.11A 5v9jB-5vsdA:
43.4
5v9jB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
8 / 12 SER A1172
TYR A1173
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.78A 5v9jB-5vsdA:
43.4
5v9jB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.45A 5vscA-5vsdA:
40.7
5vscA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.38A 5vscA-5vsdA:
40.7
5vscA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 MET A1136
GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.33A 5vscB-5vsdA:
40.9
5vscB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.34A 5vscB-5vsdA:
40.9
5vscB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.40A 5vsdA-5vsdA:
45.2
5vsdA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.46A 5vsdA-5vsdA:
45.2
5vsdA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
None
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.01A 5vsdA-5vsdA:
45.2
5vsdA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.42A 5vsdB-5vsdA:
43.5
5vsdB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.46A 5vsdB-5vsdA:
43.5
5vsdB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.17A 5vsdB-5vsdA:
43.5
5vsdB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.47A 5vseA-5vsdA:
40.4
5vseA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.37A 5vseA-5vsdA:
40.4
5vseA-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 MET A1136
GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.35A 5vseB-5vsdA:
40.8
5vseB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
11 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
0.36A 5vseB-5vsdA:
40.8
5vseB-5vsdA:
77.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.41A 5vsfA-5vsdA:
43.6
5vsfA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.43A 5vsfA-5vsdA:
43.6
5vsfA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
None
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.11A 5vsfA-5vsdA:
43.6
5vsfA-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.41A 5vsfB-5vsdA:
43.3
5vsfB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 MET A1136
GLY A1137
TRP A1138
HIS A1202
CYH A1258
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
None
ZN  A3005 (-2.3A)
1.47A 5vsfB-5vsdA:
43.3
5vsfB-5vsdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
12 / 12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYH A1256
ARG A1257
SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
SAM  A3001 (-4.3A)
0.13A 5vsfB-5vsdA:
43.3
5vsfB-5vsdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.39A 6a5kA-5vsdA:
28.4
6a5kA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.35A 6a5kA-5vsdA:
28.4
6a5kA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
HIS A1201
TYR A1242
CYH A1256
CYH A1258
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
1.17A 6a5kA-5vsdA:
28.4
6a5kA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
8 / 12 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.54A 6a5mA-5vsdA:
28.6
6a5mA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.41A 6a5mA-5vsdA:
28.6
6a5mA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.14A 6a5mA-5vsdA:
28.6
6a5mA-5vsdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
TRP A1138
ASN A1200
HIS A1201
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
ZN  A3005 ( 2.4A)
1.34A 6agoA-5vsdA:
18.2
6agoA-5vsdA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 11 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.85A 6agoA-5vsdA:
18.2
6agoA-5vsdA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 11 GLY A1137
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.94A 6agoA-5vsdA:
18.2
6agoA-5vsdA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
ARG A1197
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
0.75A 6bp4A-5vsdA:
26.8
6bp4A-5vsdA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.50A 6bp4B-5vsdA:
26.8
6bp4B-5vsdA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.31A 6bp4B-5vsdA:
26.8
6bp4B-5vsdA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
0.97A 6bp4B-5vsdA:
26.8
6bp4B-5vsdA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.45A 6bp4B-5vsdA:
26.8
6bp4B-5vsdA:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1256
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
1.50A 6cenA-5vsdA:
20.1
6cenA-5vsdA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
8 / 11 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.51A 6cenA-5vsdA:
20.1
6cenA-5vsdA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 11 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.46A 6cenA-5vsdA:
20.1
6cenA-5vsdA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
6 / 12 TRP A1138
SER A1172
TYR A1173
PHE A1198
ASN A1200
HIS A1201
None
SAM  A3001 (-3.7A)
SAM  A3001 (-4.0A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
1.15A 6chgC-5vsdA:
9.1
6chgC-5vsdA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
7 / 12 GLY A1137
TRP A1138
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
0.39A 6ineA-5vsdA:
17.9
6ineA-5vsdA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo
sapiens)
5 / 12 GLY A1137
TRP A1138
HIS A1201
TYR A1242
CYH A1258
SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
1.31A 6ineA-5vsdA:
17.9
6ineA-5vsdA:
26.35