SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		3 / 3 TRP A 114
ARG A 191
THR A 113
 None
 1.00A 1df7A-5vsjA:
undetectable		 1df7A-5vsjA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 7 ARG A 497
GLU A 495
PRO A 655
ALA A 656
 None
 1.05A 2ejfA-5vsjA:
undetectable		 2ejfA-5vsjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		3 / 3 GLU A 205
GLY A  98
THR A  99
 None
 0.59A 3iazA-5vsjA:
undetectable		 3iazA-5vsjA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		3 / 3 THR A 660
ASN A 566
GLU A 633
 None
 0.77A 3v4tA-5vsjA:
0.3
3v4tC-5vsjA:
0.3		 3v4tA-5vsjA:
21.19
3v4tC-5vsjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 LEU A 239
LEU A 319
PHE A 303
PRO A 253
ASP A 302
 None
 1.44A 4j7xJ-5vsjA:
undetectable		 4j7xJ-5vsjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 6 ARG A 648
ASN A 602
GLY A 490
THR A 654
 None
 0.97A 4l1aB-5vsjA:
undetectable		 4l1aB-5vsjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		3 / 3 ARG A 220
HIS A 229
SER A 221
 None
 0.64A 4mjwA-5vsjA:
undetectable
4mjwB-5vsjA:
undetectable		 4mjwA-5vsjA:
24.75
4mjwB-5vsjA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		3 / 3 SER A 221
ARG A 220
HIS A 229
 None
 0.63A 4mjwA-5vsjA:
undetectable
4mjwB-5vsjA:
undetectable		 4mjwA-5vsjA:
24.75
4mjwB-5vsjA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 5 ASN A 519
LEU A 482
LEU A 522
ASN A 267
 None
 1.10A 4n09C-5vsjA:
undetectable		 4n09C-5vsjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 8 ALA A 136
GLU A 133
ASP A 127
ILE A 122
 None
 0.85A 4ndnD-5vsjA:
undetectable		 4ndnD-5vsjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 5 GLN A 536
LEU A 537
SER A 221
ASP A 394
 None
None
None
9HV  A 701 (-2.9A)
 1.34A 4qtuD-5vsjA:
undetectable		 4qtuD-5vsjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 509
ALA A 244
MET A 245
GLY A 246
PHE A 247
 None
 1.03A 4r29A-5vsjA:
undetectable		 4r29A-5vsjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 509
ALA A 244
MET A 245
GLY A 246
PHE A 247
 None
 1.02A 4r29B-5vsjA:
undetectable		 4r29B-5vsjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 509
ALA A 244
MET A 245
GLY A 246
PHE A 247
 None
 1.00A 4r29C-5vsjA:
undetectable		 4r29C-5vsjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 509
ALA A 244
MET A 245
GLY A 246
PHE A 247
 None
 1.01A 4r29D-5vsjA:
undetectable		 4r29D-5vsjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 509
SER A 505
ALA A 498
ALA A 476
TYR A 514
 None
 1.48A 4ymgA-5vsjA:
undetectable		 4ymgA-5vsjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 GLY A 223
LEU A 252
ILE A 390
LEU A 239
THR A 231
 None
 1.00A 4ze2A-5vsjA:
undetectable		 4ze2A-5vsjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 8 ALA A 136
GLU A 133
ASP A 127
ILE A 122
 None
 0.81A 5t8sA-5vsjA:
undetectable		 5t8sA-5vsjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		5 / 12 ALA A  37
SER A 101
ALA A  39
PRO A  28
PHE A  45
 None
 1.34A 5zvgA-5vsjA:
undetectable		 5zvgA-5vsjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1
(Streptomyces
coelicolor) 		4 / 7 ALA A 136
GLU A 133
ASP A 127
ILE A 122
 None
 0.90A 6fbnA-5vsjA:
undetectable		 6fbnA-5vsjA:
20.21