SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 6 ASP A 231
ASP A 233
ASN A 235
GLU A 275
None
1.32A 1rjdC-5vslA:
undetectable
1rjdC-5vslA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
3 / 3 THR A  97
GLU A 257
HIS A  79
None
0.81A 1xwfA-5vslA:
undetectable
1xwfA-5vslA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
3 / 3 THR A  97
GLU A 257
HIS A  79
None
0.77A 1xwfB-5vslA:
undetectable
1xwfB-5vslA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
3 / 3 THR A  97
GLU A 257
HIS A  79
None
0.79A 1xwfC-5vslA:
undetectable
1xwfC-5vslA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
3 / 3 THR A  97
GLU A 257
HIS A  79
None
0.77A 1xwfD-5vslA:
undetectable
1xwfD-5vslA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 8 CYH A  91
GLU A 127
SER A 180
VAL A 224
SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
0.73A 2fb2A-5vslA:
18.5
2fb2A-5vslA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 LEU A 148
LEU A 150
ALA A 106
VAL A  76
PHE A 311
None
1.04A 3b0wA-5vslA:
undetectable
3b0wA-5vslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 7 TYR A  78
LEU A 101
VAL A 100
THR A  97
None
1.08A 3fwgB-5vslA:
undetectable
3fwgB-5vslA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 7 MET A 309
LEU A 101
LEU A 113
PHE A 311
None
1.22A 3nk2X-5vslA:
undetectable
3nk2X-5vslA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 CYH A  91
GLU A 127
PRO A 128
SER A 180
VAL A 224
SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
None
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
0.52A 3rfaB-5vslA:
4.7
3rfaB-5vslA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 PHE A  90
CYH A  91
PRO A 128
SER A 180
VAL A 224
SAH  A 402 (-4.7A)
SF4  A 401 ( 2.4A)
None
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
0.88A 3rfaB-5vslA:
4.7
3rfaB-5vslA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 8 SER A 273
ARG A 283
ILE A 272
GLU A 275
None
1.25A 4cx7A-5vslA:
undetectable
4cx7B-5vslA:
undetectable
4cx7A-5vslA:
22.22
4cx7B-5vslA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 8 SER A 273
ARG A 283
ILE A 272
GLU A 275
None
1.22A 4cx7C-5vslA:
undetectable
4cx7D-5vslA:
undetectable
4cx7C-5vslA:
22.22
4cx7D-5vslA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 ALA A 106
PHE A  80
SER A 124
PHE A 129
VAL A 100
None
None
SAH  A 402 (-3.2A)
None
None
1.11A 4eckB-5vslA:
undetectable
4eckB-5vslA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 4 ILE A 121
LEU A 118
LYS A 120
ASN A  77
None
1.29A 4g19D-5vslA:
undetectable
4g19D-5vslA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
6 / 12 GLU A 127
ASN A 158
SER A 180
VAL A 224
CYH A 251
LEU A 252
SAH  A 402 (-4.3A)
SF4  A 401 ( 4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-3.8A)
SAH  A 402 (-4.5A)
0.43A 4k36A-5vslA:
19.2
4k36A-5vslA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 SER A 180
ARG A 194
VAL A 224
CYH A 251
LEU A 252
SAH  A 402 (-2.4A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-3.8A)
SAH  A 402 (-4.5A)
0.81A 4k36A-5vslA:
19.2
4k36A-5vslA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 CYH A  91
ARG A 194
VAL A 224
CYH A 251
LEU A 252
SF4  A 401 ( 2.4A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-3.8A)
SAH  A 402 (-4.5A)
0.84A 4k36B-5vslA:
19.6
4k36B-5vslA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
6 / 12 CYH A  91
GLU A 127
ASN A 158
VAL A 224
CYH A 251
LEU A 252
SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SF4  A 401 ( 4.3A)
SAH  A 402 (-4.3A)
SAH  A 402 (-3.8A)
SAH  A 402 (-4.5A)
0.48A 4k36B-5vslA:
19.6
4k36B-5vslA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
6 / 11 CYH A  91
GLU A 127
SER A 180
ARG A 194
VAL A 224
LEU A 252
SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
0.78A 4k37A-5vslA:
19.4
4k37A-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 11 GLU A 127
ASN A 158
SER A 180
VAL A 224
LEU A 252
SAH  A 402 (-4.3A)
SF4  A 401 ( 4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
0.41A 4k37B-5vslA:
19.4
4k37B-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 CYH A  91
GLU A 127
ARG A 194
VAL A 224
LEU A 252
SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
0.83A 4k38B-5vslA:
19.8
4k38B-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 GLU A 127
ASN A 158
SER A 180
VAL A 224
LEU A 252
SAH  A 402 (-4.3A)
SF4  A 401 ( 4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-4.5A)
0.51A 4k39A-5vslA:
19.2
4k39A-5vslA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
4 / 6 HIS A  79
TYR A 302
PHE A  92
ASN A 258
None
None
SAH  A 402 (-3.6A)
SAH  A 402 (-4.4A)
1.31A 4o7gB-5vslA:
undetectable
4o7gB-5vslA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_B_SAMB401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 10 CYH A  88
GLU A 127
PRO A 128
HIS A 201
ASN A 226
SF4  A 401 (-2.4A)
SAH  A 402 (-4.3A)
None
None
None
1.38A 4pl1B-5vslA:
16.3
4pl1B-5vslA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 SER A 259
GLY A 260
ALA A 263
GLU A 268
THR A  94
None
1.20A 4xt8A-5vslA:
2.0
4xt8A-5vslA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 12 ILE A 162
LEU A 174
GLY A 171
PHE A 167
ILE A 155
None
1.05A 5j7wD-5vslA:
undetectable
5j7wD-5vslA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
5 / 11 GLU A 127
SER A 180
ARG A 194
LEU A 252
ALA A 267
SAH  A 402 (-4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.5A)
None
0.91A 6efnA-5vslA:
5.6
6efnA-5vslA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
3 / 3 HIS A  79
ASN A  77
LEU A 303
None
0.88A 6f7lB-5vslA:
undetectable
6f7lB-5vslA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus
musculus)
6 / 12 LEU A 208
ILE A 162
LEU A 174
GLY A 171
PHE A 167
ILE A 155
None
1.34A 6qxsB-5vslA:
undetectable
6qxsB-5vslA:
25.42