SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vtm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 12 ALA X 244
LEU X 260
VAL X 224
LEU X 227
ALA X 228
None
0.83A 1jipA-5vtmX:
undetectable
1jipA-5vtmX:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 ARG W 122
ARG W 137
ARG W  59
None
1.12A 1l7fA-5vtmW:
undetectable
1l7fA-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 ASP X 187
VAL X 188
SER X 209
GLN X 315
None
1.47A 1n2xB-5vtmX:
undetectable
1n2xB-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
3 / 3 ALA W  53
VAL W  51
TRP V  48
None
0.89A 1nt6A-5vtmW:
undetectable
1nt6A-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
3 / 3 ALA W  53
VAL W  51
TRP V  48
None
0.89A 1nt6B-5vtmW:
undetectable
1nt6B-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 12 LEU X 196
LEU X 194
ALA X 166
GLU X 167
ILE X 142
None
None
None
CA  X 403 ( 2.2A)
None
0.98A 1s9pC-5vtmX:
undetectable
1s9pC-5vtmX:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
5 / 9 LEU W 115
ALA W  53
LEU W  50
GLU W  58
LEU W  61
None
1.42A 2azqA-5vtmW:
undetectable
2azqA-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 ARG W 105
VAL W  69
THR W  93
None
0.80A 2nmzA-5vtmW:
undetectable
2nmzA-5vtmW:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 ASN W 158
LEU W 153
HIS W 157
None
0.74A 2q6fB-5vtmW:
undetectable
2q6fB-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 12 LEU X 196
LEU X 146
LEU X 115
VAL X 126
VAL X 208
None
1.35A 2qd4B-5vtmX:
undetectable
2qd4B-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 11 LEU W  73
ARG W  70
VAL W  69
LEU X 172
ASP X 168
None
1.16A 2qeiA-5vtmW:
undetectable
2qeiA-5vtmW:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
3 / 3 GLN X 251
THR X 221
TRP X  84
None
1.05A 2rctA-5vtmX:
undetectable
2rctA-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 8 ARG X 300
ARG X  86
TRP X  84
THR X 221
CA  X 401 ( 4.5A)
None
None
None
1.40A 2vxaF-5vtmX:
undetectable
2vxaG-5vtmX:
undetectable
2vxaI-5vtmX:
undetectable
2vxaF-5vtmX:
27.50
2vxaG-5vtmX:
27.50
2vxaI-5vtmX:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
3 / 3 TRP X  48
VAL W 111
ARG W 123
None
0.96A 3b0wA-5vtmX:
undetectable
3b0wA-5vtmX:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
5 / 12 LEU X  99
TYR X  50
GLY V 123
GLY X  53
LEU X  57
None
1.16A 3e23A-5vtmX:
undetectable
3e23A-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 9 ASP W  75
ASP W  71
ASN X 182
ASP X 157
ASP X 168
None
None
CA  X 403 (-3.1A)
CA  X 402 ( 2.7A)
None
1.42A 3havB-5vtmW:
0.0
3havB-5vtmW:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 THR X 221
SER X 107
SER X 209
ARG X 109
None
1.45A 3hlwB-5vtmX:
undetectable
3hlwB-5vtmX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 ARG W 105
VAL W  69
THR W  93
None
0.82A 3ndtA-5vtmW:
undetectable
3ndtA-5vtmW:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 GLY X 275
ASP X  78
ARG X 277
GLN X 280
None
CA  X 401 (-3.3A)
None
None
1.49A 3qx3A-5vtmX:
undetectable
3qx3A-5vtmX:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 ARG W 112
ARG W 110
ILE W  89
None
0.93A 4b7qA-5vtmW:
undetectable
4b7qA-5vtmW:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
4 / 7 GLN W 140
VAL W 138
GLU W 121
ARG W 123
None
1.01A 4mv7A-5vtmW:
undetectable
4mv7A-5vtmW:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 TYR X 201
ARG X 192
GLU X 190
VAL W  69
None
1.31A 4nkvB-5vtmX:
undetectable
4nkvB-5vtmX:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 12 VAL X 226
PRO X 225
ALA X 228
PHE X 250
ILE X 241
None
1.42A 5hgcA-5vtmX:
undetectable
5hgcA-5vtmX:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 PRO X 235
ALA X 238
ALA X 228
ILE X 233
None
0.74A 5jncD-5vtmX:
undetectable
5jncD-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 4 PHE X 256
ASP X 255
LEU X 260
LYS X 258
None
1.19A 6awvA-5vtmX:
undetectable
6awvA-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
3 / 3 GLY W 117
THR W 119
GLU W 121
None
0.63A 6b58A-5vtmW:
undetectable
6b58A-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa)
5 / 12 VAL W 181
PRO W 136
PHE W 152
PHE W  80
GLN W 139
None
1.40A 6becA-5vtmW:
undetectable
6becB-5vtmW:
undetectable
6becC-5vtmW:
undetectable
6becA-5vtmW:
12.22
6becB-5vtmW:
12.22
6becC-5vtmW:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 LEU W 174
THR W 165
ARG X 307
PRO W 203
None
1.41A 6ew0B-5vtmW:
undetectable
6ew0B-5vtmW:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 LEU W 174
THR W 165
ARG X 307
PRO W 203
None
1.41A 6ew0D-5vtmW:
undetectable
6ew0D-5vtmW:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 LEU W 174
THR W 165
ARG X 307
PRO W 203
None
1.41A 6ew0H-5vtmW:
undetectable
6ew0H-5vtmW:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 5 LEU W 174
THR W 165
ARG X 307
PRO W 203
None
1.41A 6ew0I-5vtmW:
undetectable
6ew0I-5vtmW:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
4 / 8 ARG X 192
VAL W  69
ARG W 122
GLN W 139
None
1.21A 6fbvD-5vtmX:
undetectable
6fbvD-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 7 ASP X 155
ASP X 157
GLN X 161
TYR X 171
CA  X 402 ( 2.2A)
CA  X 402 ( 2.7A)
None
None
1.22A 6g31G-5vtmX:
undetectable
6g31G-5vtmX:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
4 / 6 LEU X 205
ASP X 187
GLN X 315
GLN X 280
None
1.37A 6g31J-5vtmX:
undetectable
6g31J-5vtmX:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa)
5 / 11 LEU X 132
THR X 135
ILE X 233
ALA X 238
ALA X 222
None
1.02A 6h1lB-5vtmX:
undetectable
6h1lB-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
5 / 10 TRP X  48
GLY V 126
LEU X  52
GLY X  53
LEU W 108
None
1.37A 6hqbA-5vtmX:
undetectable
6hqbJ-5vtmX:
undetectable
6hqbA-5vtmX:
21.35
6hqbJ-5vtmX:
19.75