SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		5 / 9 GLY A 101
ASP A  80
ILE A  93
VAL A 132
ILE A 106
 None
 1.09A 1hxwA-5vtoA:
undetectable		 1hxwA-5vtoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 4 GLY A 101
SER A  99
ILE A 106
HIS A 103
 None
 1.24A 1yajJ-5vtoA:
undetectable		 1yajJ-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 5 ALA A  21
ASN A  59
ILE A  84
ASP A  80
 None
 1.03A 2h4jA-5vtoA:
6.6		 2h4jA-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		5 / 10 GLN A  53
ILE A  47
LEU A 119
VAL A 117
VAL A 144
 None
 1.07A 3gwxA-5vtoA:
undetectable		 3gwxA-5vtoA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		5 / 11 ILE A 160
VAL A  89
PHE A  90
VAL A  18
ILE A 116
 None
 1.39A 3rf4A-5vtoA:
undetectable
3rf4C-5vtoA:
undetectable		 3rf4A-5vtoA:
20.33
3rf4C-5vtoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		3 / 3 ARG A  62
ARG A  63
ILE A  47
 None
 0.91A 4b7qC-5vtoA:
undetectable		 4b7qC-5vtoA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		3 / 3 GLU A  83
LYS A  86
ASN A  59
 None
 1.00A 4y1dA-5vtoA:
undetectable
4y1dD-5vtoA:
undetectable		 4y1dA-5vtoA:
undetectable
4y1dD-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 4 LEU A 131
ILE A 106
GLY A 134
ILE A 116
 None
 0.78A 5dzk3-5vtoA:
undetectable
5dzkm-5vtoA:
undetectable		 5dzk3-5vtoA:
undetectable
5dzkm-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 6 SER A  99
HIS A 103
LEU A 118
LEU A 120
 None
 1.37A 5dzke-5vtoA:
undetectable
5dzks-5vtoA:
undetectable		 5dzke-5vtoA:
undetectable
5dzks-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 5 ILE A 106
GLY A 134
ILE A 116
LEU A 131
 None
 0.87A 5dzki-5vtoA:
undetectable
5dzkj-5vtoA:
undetectable
5dzkx-5vtoA:
undetectable		 5dzki-5vtoA:
undetectable
5dzkj-5vtoA:
undetectable
5dzkx-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 5 ILE A 106
GLY A 134
ILE A 116
LEU A 131
 None
 0.83A 5dzkd-5vtoA:
undetectable
5dzkk-5vtoA:
undetectable
5dzky-5vtoA:
undetectable		 5dzkd-5vtoA:
undetectable
5dzkk-5vtoA:
undetectable
5dzky-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		4 / 4 ILE A 106
GLY A 134
ILE A 116
LEU A 131
 None
 0.86A 5dzkl-5vtoA:
undetectable
5dzkz-5vtoA:
undetectable		 5dzkl-5vtoA:
undetectable
5dzkz-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5vto BLASTICIDIN M
(Streptomyces
griseochromogene
s) 		5 / 12 LEU A  20
HIS A  61
ALA A  65
GLY A  26
LEU A  27
 None
 0.99A 6b0iB-5vtoA:
3.8		 6b0iB-5vtoA:
21.95