SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 5 LEU M  33
ASN M   9
VAL M 163
ALA M 131
 None
 0.96A 2cizA-5vu2M:
undetectable		 2cizA-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 LEU M  33
ASN M   9
VAL M 163
ALA M 131
 None
 0.98A 2j5mA-5vu2M:
undetectable		 2j5mA-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 LEU M  38
LEU M  33
VAL M 163
GLY M 164
 None
 0.90A 2po5A-5vu2M:
undetectable		 2po5A-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 ALA M 336
ALA M 359
SER M 309
GLY M 313
 None
 0.93A 2vh3B-5vu2M:
undetectable		 2vh3B-5vu2M:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5vu2 CAPSID PROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus;
Chikungunya
virus) 		4 / 7 THR Q 403
PRO Q 404
GLY Q 405
PHE I 178
 None
 0.99A 2vl2B-5vu2Q:
undetectable		 2vl2B-5vu2Q:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 THR M 217
VAL M 108
SER M 111
SER M 113
GLY M 239
 None
 1.16A 2x2iC-5vu2M:
undetectable		 2x2iC-5vu2M:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 PRO M  58
GLN M 102
PRO M  86
TYR M  93
 None
 1.19A 3vkxA-5vu2M:
undetectable		 3vkxA-5vu2M:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 ASP M 188
ARG M 123
LYS M 176
 None
 1.06A 3wipG-5vu2M:
3.1		 3wipG-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5vu2 CAPSID PROTEIN
(Chikungunya
virus) 		3 / 3 ARG I 215
HIS I 190
TYR I 126
 None
 1.02A 4fu8A-5vu2I:
4.1		 4fu8A-5vu2I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5vu2 CAPSID PROTEIN
(Chikungunya
virus) 		3 / 3 ARG I 215
HIS I 190
TYR I 126
 None
 1.11A 4fu9A-5vu2I:
3.3		 4fu9A-5vu2I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5vu2 E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 10 TYR Q 363
ILE Q 356
ILE Q 355
THR Q 367
ILE Q 370
 None
 1.03A 5mzrA-5vu2Q:
undetectable		 5mzrA-5vu2Q:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5vu2 E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 10 TYR Q 363
ILE Q 356
ILE Q 355
THR Q 367
ILE Q 370
 None
 1.04A 5mzrC-5vu2Q:
undetectable		 5mzrC-5vu2Q:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 GLY M 201
PHE M 240
ARG M 206
ASP M 202
 None
 0.90A 5n5dB-5vu2M:
undetectable		 5n5dB-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5vu2 CAPSID PROTEIN
(Chikungunya
virus) 		4 / 7 VAL I 243
VAL I 250
LYS I 252
ASP I 161
 None
 0.89A 5yf9B-5vu2I:
undetectable		 5yf9B-5vu2I:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5vu2 E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 9 ILE M 142
ALA M 159
LEU M  29
PRO M  14
ARG M 134
 None
 1.45A 5z6lA-5vu2M:
undetectable		 5z6lA-5vu2M:
undetectable