SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  40
ALA A  15
VAL A  11
 GOL  A 302 (-4.3A)
None
None
 0.86A 1bdwA-5vugA:
undetectable
1bdwB-5vugA:
undetectable		 1bdwA-5vugA:
4.76
1bdwB-5vugA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 135
ILE A 157
ARG A  14
LEU A 139
 None
 0.88A 1iepB-5vugA:
undetectable		 1iepB-5vugA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  53
ALA A  31
ALA A  15
VAL A  43
LEU A 123
 None
 1.16A 1rlbF-5vugA:
undetectable		 1rlbF-5vugA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  15
ALA A  12
ILE A  28
THR A 113
 None
 0.59A 3dtuC-5vugA:
undetectable
3dtuD-5vugA:
undetectable		 3dtuC-5vugA:
18.92
3dtuD-5vugA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 248
VAL A  11
ILE A 260
GLY A 245
 None
 0.92A 3hjoA-5vugA:
undetectable		 3hjoA-5vugA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 248
VAL A  11
ILE A 260
GLY A 245
 None
 0.90A 3hjoB-5vugA:
undetectable		 3hjoB-5vugA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 243
VAL A 265
TRP A 227
 None
 0.92A 3l8lC-5vugA:
undetectable
3l8lD-5vugA:
undetectable		 3l8lC-5vugA:
4.76
3l8lD-5vugA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 110
LEU A 106
THR A 142
GLY A 143
GLY A 146
 None
 1.12A 4bwlC-5vugA:
3.2		 4bwlC-5vugA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5vug UNCHARACTERIZED
PROTEIN RV2277C
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 106
THR A 105
PRO A 104
VAL A  25
 None
 0.89A 4qknA-5vugA:
undetectable		 4qknA-5vugA:
18.66