SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		4 / 5 THR A  22
LEU A  94
GLY A  96
LYS A  99
 GOL  A 300 (-2.8A)
None
None
None
 1.23A 1gtiF-5vveA:
undetectable		 1gtiF-5vveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 11 LEU A 217
LEU A 194
LEU A 190
ILE A 168
ALA A 169
 None
 1.05A 1ha2A-5vveA:
undetectable		 1ha2A-5vveA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		4 / 7 ASP A  52
PHE A  51
ARG A 177
ALA A  75
 None
 1.28A 2e5dA-5vveA:
undetectable
2e5dB-5vveA:
undetectable		 2e5dA-5vveA:
20.49
2e5dB-5vveA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 12 ILE A 180
ALA A 182
ARG A 159
LEU A  86
VAL A 172
 None
 1.04A 3dzuA-5vveA:
undetectable		 3dzuA-5vveA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 12 ALA A  62
GLY A  23
SER A  57
LEU A  86
SER A 186
 None
 1.04A 3gyqA-5vveA:
undetectable
3gyqB-5vveA:
undetectable		 3gyqA-5vveA:
19.23
3gyqB-5vveA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 11 GLY A  41
MET A  73
ILE A  43
GLY A  11
ILE A   8
 None
 1.10A 4qoiA-5vveA:
undetectable
4qoiB-5vveA:
undetectable		 4qoiA-5vveA:
24.65
4qoiB-5vveA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		4 / 8 TYR A 215
ASP A 195
ILE A 224
TYR A 227
 None
 0.86A 4xjeA-5vveA:
undetectable		 4xjeA-5vveA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		4 / 5 SER A 186
GLY A 210
THR A  32
GLU A  36
 None
 1.18A 5btiA-5vveA:
undetectable
5btiB-5vveA:
undetectable		 5btiA-5vveA:
18.11
5btiB-5vveA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		4 / 4 CYH A  54
LEU A  70
LEU A  66
ALA A  69
 None
 1.13A 5hpuA-5vveA:
undetectable
5hpuB-5vveA:
undetectable		 5hpuA-5vveA:
6.09
5hpuB-5vveA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_D_MMSD515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 9 HIS A  10
HIS A 183
LEU A 187
THR A  56
SER A  57
 GOL  A 300 (-4.2A)
GOL  A 300 (-4.4A)
None
None
None
 1.28A 5m8nD-5vveA:
undetectable		 5m8nD-5vveA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5vve PHOSPHOGLYCERATE
MUTASE
(Naegleria
fowleri) 		5 / 12 LEU A 217
LEU A 194
LEU A 190
ILE A 168
ALA A 169
 None
 1.16A 5v0vA-5vveA:
undetectable		 5v0vA-5vveA:
17.78