SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5vvm CADHERIN-23
(Homo
sapiens) 		5 / 12 LEU A2399
ALA A2403
PRO A2377
VAL A2470
LEU A2413
 None
 1.26A 1cbrA-5vvmA:
undetectable		 1cbrA-5vvmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5vvm CADHERIN-23
(Homo
sapiens) 		5 / 12 LEU A2399
ALA A2403
PRO A2377
VAL A2470
LEU A2413
 None
 1.26A 1cbrB-5vvmA:
undetectable		 1cbrB-5vvmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5vvm CADHERIN-23
(Homo
sapiens) 		5 / 10 ALA A2209
GLN A2156
LEU A2256
ASN A2172
LEU A2235
 None
 1.10A 2riwA-5vvmA:
undetectable
2riwB-5vvmA:
undetectable		 2riwA-5vvmA:
20.09
2riwB-5vvmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5vvm CADHERIN-23
(Homo
sapiens) 		4 / 6 VAL A2217
LEU A2235
ILE A2188
VAL A2258
 None
 0.91A 4a9kA-5vvmA:
undetectable		 4a9kA-5vvmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5vvm CADHERIN-23
(Homo
sapiens) 		4 / 6 TYR A2186
ASP A2179
HIS A2178
ILE A2176
 None
 0.85A 5ih0A-5vvmA:
undetectable		 5ih0A-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5vvm CADHERIN-23
(Homo
sapiens) 		3 / 3 GLY A2215
THR A2174
ASN A2172
 None
 0.66A 5odiG-5vvmA:
undetectable		 5odiG-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vvm CADHERIN-23
(Homo
sapiens) 		4 / 8 VAL A2337
PRO A2317
ILE A2282
TYR A2339
 None
 0.97A 6cduG-5vvmA:
undetectable
6cduH-5vvmA:
undetectable		 6cduG-5vvmA:
undetectable
6cduH-5vvmA:
undetectable