SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 5 PHE A 145
GLY A 140
THR A 217
PHE A 173
 None
 1.32A 1icuC-5vvoA:
undetectable
1icuD-5vvoA:
undetectable		 1icuC-5vvoA:
17.55
1icuD-5vvoA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 5 PHE A 145
GLY A 140
THR A 217
PHE A 173
 None
 1.32A 1icvA-5vvoA:
undetectable
1icvB-5vvoA:
undetectable		 1icvA-5vvoA:
17.55
1icvB-5vvoA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.34A 1lqtB-5vvoA:
undetectable		 1lqtB-5vvoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		3 / 3 ALA A 192
HIS A 193
VAL A 196
 None
 0.35A 1lquB-5vvoA:
undetectable		 1lquB-5vvoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		3 / 3 PHE A 214
TYR A 233
PRO A 216
 None
 1.05A 1mcnA-5vvoA:
undetectable
1mcnB-5vvoA:
undetectable
1mcnP-5vvoA:
undetectable		 1mcnA-5vvoA:
18.72
1mcnB-5vvoA:
18.72
1mcnP-5vvoA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.47A 1nsiA-5vvoA:
undetectable
1nsiB-5vvoA:
undetectable		 1nsiA-5vvoA:
20.35
1nsiB-5vvoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 6 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.48A 1nsiC-5vvoA:
undetectable
1nsiD-5vvoA:
undetectable		 1nsiC-5vvoA:
20.35
1nsiD-5vvoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 6 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.49A 1nsiC-5vvoA:
undetectable
1nsiD-5vvoA:
undetectable		 1nsiC-5vvoA:
20.35
1nsiD-5vvoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 8 THR A  92
LEU A 311
VAL A 276
GLY A 309
 None
 0.93A 2a1oA-5vvoA:
undetectable		 2a1oA-5vvoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		6 / 11 ASP A 174
CYH A 215
TYR A 219
THR A 250
VAL A 254
TYR A 286
 None
 0.87A 2w4xA-5vvoA:
31.7		 2w4xA-5vvoA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		9 / 11 CYH A 215
TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 None
 0.42A 2w4xA-5vvoA:
31.7		 2w4xA-5vvoA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		6 / 12 ASP A 174
TYR A 219
VAL A 254
ASN A 280
ASP A 285
ASN A 313
 None
 0.79A 2x0yA-5vvoA:
38.7		 2x0yA-5vvoA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		7 / 12 TYR A 219
THR A 250
VAL A 254
TRP A 278
ASN A 280
ASP A 285
ASN A 313
 None
 0.40A 2x0yA-5vvoA:
38.7		 2x0yA-5vvoA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		8 / 12 ASP A 174
TYR A 219
THR A 250
TRP A 278
ASN A 280
ASP A 285
TYR A 286
ASN A 313
 None
 0.74A 2x0yB-5vvoA:
39.8		 2x0yB-5vvoA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 7 SER A 268
VAL A 228
ILE A 271
TRP A 249
 None
 1.19A 2x45B-5vvoA:
undetectable		 2x45B-5vvoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 7 SER A 268
VAL A 228
ILE A 271
TRP A 249
 None
 1.16A 2x45C-5vvoA:
undetectable		 2x45C-5vvoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 PRO A 209
ILE A 134
LEU A 171
ALA A  96
LEU A 248
 None
 1.10A 3a50D-5vvoA:
undetectable		 3a50D-5vvoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 10 PHE A 133
ILE A 137
LEU A 248
VAL A 276
LEU A 311
 None
 1.03A 3gwxA-5vvoA:
undetectable		 3gwxA-5vvoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 7 SER A 162
LEU A  94
ILE A 123
PHE A 133
 None
 1.08A 3ln1C-5vvoA:
1.6		 3ln1C-5vvoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 ARG A 580
LEU A 564
GLY A 575
ALA A 576
LEU A 701
 None
 1.14A 4coxA-5vvoA:
undetectable		 4coxA-5vvoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 ARG A 580
LEU A 564
GLY A 575
ALA A 576
LEU A 701
 None
 1.16A 4coxD-5vvoA:
undetectable		 4coxD-5vvoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.26A 4d33A-5vvoA:
undetectable		 4d33A-5vvoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 5 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.27A 4d33B-5vvoA:
undetectable		 4d33B-5vvoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 8 ILE A 325
ILE A 131
LYS A 308
GLY A 309
 None
 0.93A 4hdlA-5vvoA:
undetectable		 4hdlA-5vvoA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		3 / 3 LYS A 289
ASN A 315
ASP A 646
 None
 0.83A 4o1eA-5vvoA:
8.2		 4o1eA-5vvoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 7 GLU A 117
GLU A  76
TRP A  73
ASP A 639
 None
 1.15A 4uacA-5vvoA:
undetectable		 4uacA-5vvoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.36A 4uroA-5vvoA:
undetectable		 4uroA-5vvoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.38A 4uroB-5vvoA:
undetectable		 4uroB-5vvoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
 None
 1.37A 4uroD-5vvoA:
undetectable		 4uroD-5vvoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 6 LEU A  94
GLU A 132
ILE A 137
HIS A 103
 None
 0.96A 4xi3C-5vvoA:
undetectable		 4xi3C-5vvoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.22A 4zdyA-5vvoA:
undetectable		 4zdyA-5vvoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.16A 4ze2A-5vvoA:
undetectable		 4ze2A-5vvoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.16A 5eslA-5vvoA:
undetectable		 5eslA-5vvoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		5 / 10 LEU A 248
PRO A 275
GLY A 251
VAL A 310
LEU A 311
 None
 1.01A 5o96E-5vvoA:
3.4
5o96F-5vvoA:
2.8		 5o96E-5vvoA:
20.16
5o96F-5vvoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vvo PROTEIN O-GLCNACASE
(Homo
sapiens) 		4 / 7 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.35A 5vurA-5vvoA:
1.0
5vurB-5vvoA:
undetectable		 5vurA-5vvoA:
21.05
5vurB-5vvoA:
21.05