SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 ILE M 336
LEU M 444
LEU M 350
HIS M 341
ILE M 445
 None
 1.20A 1fmlB-5vvrM:
undetectable		 1fmlB-5vvrM:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 10 LEU M 488
LYS M 487
VAL M 461
PRO M 348
LEU M 350
 None
 1.21A 1sv5A-5vvrM:
undetectable		 1sv5A-5vvrM:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 ILE M 330
ILE M 333
ALA M 334
ILE M 494
PHE M 365
 None
 1.22A 1xzxX-5vvrM:
undetectable		 1xzxX-5vvrM:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 PRO M 754
ALA M 742
ALA M 670
MET M 583
ILE M 747
 None
 1.09A 2jjpA-5vvrM:
undetectable		 2jjpA-5vvrM:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		4 / 6 GLU M 470
PRO M 477
ARG M 475
GLY M 471
 None
 1.39A 3oxvA-5vvrM:
undetectable		 3oxvA-5vvrM:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 ILE M 494
LEU M 308
GLY M 321
ILE M 319
ASN M 503
 None
 1.20A 4o1eA-5vvrM:
undetectable		 4o1eA-5vvrM:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		4 / 4 THR M 506
GLU M 507
THR M 499
HIS M 472
 None
 1.46A 4ydqA-5vvrM:
undetectable		 4ydqA-5vvrM:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 GLY M 450
ILE M 319
GLY M 321
GLY M 498
THR M 447
 None
 1.12A 5eqbA-5vvrM:
undetectable		 5eqbA-5vvrM:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		4 / 4 THR M 506
GLU M 507
THR M 499
HIS M 472
 None
 1.31A 5f9zA-5vvrM:
undetectable		 5f9zA-5vvrM:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		4 / 4 THR M 506
GLU M 507
THR M 499
HIS M 472
 None
 1.31A 5f9zB-5vvrM:
undetectable		 5f9zB-5vvrM:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 VAL M 349
ILE M 333
LEU M 496
VAL M 467
PHE M 365
 None
 1.21A 5im2A-5vvrM:
2.6		 5im2A-5vvrM:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		3 / 3 LYS M 239
ASP M 243
ARG M 230
 None
 0.99A 5jwaA-5vvrM:
undetectable
5jwaH-5vvrM:
undetectable		 5jwaA-5vvrM:
19.38
5jwaH-5vvrM:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 GLY M 736
ILE M 708
ARG M 711
LEU M 714
GLY M 710
 None
 1.39A 6bp4B-5vvrM:
undetectable		 6bp4B-5vvrM:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26
(Saccharomyces
cerevisiae) 		5 / 12 LEU M 623
GLN M 593
CYH M 627
ARG M 624
ASP M 749
 None
 1.43A 6bxnA-5vvrM:
2.9		 6bxnA-5vvrM:
15.76