SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 147
VAL A  34
LEU A  35
LEU A 167
 None
 0.86A 1pthA-5vvwA:
undetectable		 1pthA-5vvwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 147
VAL A  34
LEU A  35
LEU A 167
 None
 0.86A 1pthB-5vvwA:
undetectable		 1pthB-5vvwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 212
LEU A 179
TYR A 199
LYS A 205
 None
 1.11A 1rmtB-5vvwA:
undetectable		 1rmtB-5vvwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 142
HIS A 116
ILE A 118
 None
 0.62A 1s9pB-5vvwA:
undetectable		 1s9pB-5vvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 297
ARG A 275
PRO A 277
ILE A 257
VAL A 232
 None
 1.42A 2ygpA-5vvwA:
undetectable		 2ygpA-5vvwA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 230
VAL A 231
THR A 129
GLY A 125
 None
 1.21A 3elzB-5vvwA:
undetectable		 3elzB-5vvwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A  93
PRO A  89
GLY A  44
VAL A  42
GLU A  41
 None
 1.17A 3jb2A-5vvwA:
4.3		 3jb2A-5vvwA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 117
VAL A 185
ALA A 121
ALA A 171
LEU A 111
LEU A 181
 None
 1.39A 3p2kD-5vvwA:
2.9		 3p2kD-5vvwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 147
GLU A 170
GLY A 150
LEU A 108
 None
 1.35A 5g5gC-5vvwA:
undetectable		 5g5gC-5vvwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 213
GLU A 173
HIS A 124
THR A 245
 None
 0.97A 5hqaA-5vvwA:
undetectable		 5hqaA-5vvwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A  18
LEU A 108
VAL A  34
LEU A 161
PHE A  20
 None
 0.75A 5tixB-5vvwA:
3.4		 5tixB-5vvwA:
19.94