SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.19A 1mj2B-5vwkA:
undetectable		 1mj2B-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.18A 1mj2D-5vwkA:
undetectable		 1mj2D-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.18A 1mjoB-5vwkA:
undetectable		 1mjoB-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.19A 1mjoA-5vwkA:
undetectable		 1mjoA-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.19A 1mjoD-5vwkA:
undetectable		 1mjoD-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 ALA A 772
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.07A 2f16H-5vwkA:
undetectable
2f16I-5vwkA:
undetectable		 2f16H-5vwkA:
21.67
2f16I-5vwkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 ALA A 772
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.08A 2f16V-5vwkA:
undetectable
2f16W-5vwkA:
undetectable		 2f16V-5vwkA:
21.67
2f16W-5vwkA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 739
ILE A 740
SER A 741
ILE A 742
VAL A 797
 None
 0.97A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 739
SER A 741
ILE A 742
VAL A 797
ARG A 801
 None
 1.03A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A 738
GLY A 739
ILE A 740
SER A 741
ILE A 742
 None
 0.75A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 ALA A 772
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.06A 3mg0V-5vwkA:
undetectable
3mg0W-5vwkA:
undetectable		 3mg0V-5vwkA:
21.67
3mg0W-5vwkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.12A 4qvpH-5vwkA:
undetectable
4qvpI-5vwkA:
undetectable		 4qvpH-5vwkA:
20.64
4qvpI-5vwkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.12A 4qvpV-5vwkA:
undetectable
4qvpW-5vwkA:
undetectable		 4qvpV-5vwkA:
20.64
4qvpW-5vwkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.15A 4qvyH-5vwkA:
undetectable		 4qvyH-5vwkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.14A 4qvyV-5vwkA:
undetectable
4qvyW-5vwkA:
undetectable		 4qvyV-5vwkA:
20.64
4qvyW-5vwkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.13A 4qw1H-5vwkA:
undetectable
4qw1I-5vwkA:
undetectable		 4qw1H-5vwkA:
20.64
4qw1I-5vwkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 734
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.13A 4qw1V-5vwkA:
undetectable
4qw1W-5vwkA:
undetectable		 4qw1V-5vwkA:
20.64
4qw1W-5vwkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 772
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.05A 6hwdH-5vwkA:
undetectable
6hwdI-5vwkA:
undetectable		 6hwdH-5vwkA:
20.77
6hwdI-5vwkA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vwk PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 ALA A 772
ALA A 803
GLY A 804
THR A 805
ALA A 806
 None
 1.05A 6hwdV-5vwkA:
undetectable		 6hwdV-5vwkA:
20.77