SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  86
GLY A 108
ALA A 107
SER A 186
LEU A 240
 None
EDO  A 405 (-3.4A)
None
EDO  A 405 (-2.8A)
None
 1.07A 1cqeA-5vwmA:
undetectable		 1cqeA-5vwmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 1.06A 1kglA-5vwmA:
undetectable		 1kglA-5vwmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 110
LEU A  95
SER A  63
MET A  62
 None
None
EDO  A 406 (-2.8A)
C90  A 401 ( 4.5A)
 1.16A 1wrlE-5vwmA:
undetectable		 1wrlE-5vwmA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  79
PHE A  39
LEU A  26
SER A  20
 None
 0.94A 1wrlE-5vwmA:
undetectable
1wrlF-5vwmA:
undetectable		 1wrlE-5vwmA:
11.92
1wrlF-5vwmA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 262
LEU A 266
ASP A 245
ASP A 241
 None
CL  A 403 (-4.5A)
None
ZN  A 402 ( 2.1A)
 1.12A 2j2pE-5vwmA:
undetectable
2j2pF-5vwmA:
undetectable		 2j2pE-5vwmA:
18.32
2j2pF-5vwmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 252
TYR A 296
PHE A 128
TYR A 247
 None
 1.21A 2x7hA-5vwmA:
undetectable		 2x7hA-5vwmA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 252
TYR A 296
PHE A 128
TYR A 247
 None
 1.19A 2x7hB-5vwmA:
undetectable		 2x7hB-5vwmA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 172
SER A 173
VAL A 174
ILE A 243
HIS A 237
 None
None
None
None
ZN  A 402 ( 3.3A)
 1.08A 4c49A-5vwmA:
undetectable		 4c49A-5vwmA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 221
LEU A 223
GLU A 225
 None
 0.70A 4l3gF-5vwmA:
undetectable		 4l3gF-5vwmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 114
MET A 297
ARG A 298
 None
 0.82A 4lnwA-5vwmA:
undetectable		 4lnwA-5vwmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 114
MET A 297
ARG A 298
 None
 0.84A 4lnxA-5vwmA:
undetectable		 4lnxA-5vwmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 241
HIS A 237
PHE A 181
ILE A 243
ALA A  84
 ZN  A 402 ( 2.1A)
ZN  A 402 ( 3.3A)
None
None
None
 1.37A 4wh5A-5vwmA:
undetectable		 4wh5A-5vwmA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  86
GLY A 108
ALA A 107
SER A 186
LEU A 240
 None
EDO  A 405 (-3.4A)
None
EDO  A 405 (-2.8A)
None
 1.07A 5kirA-5vwmA:
undetectable		 5kirA-5vwmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A  75
HIS A  78
ASP A 241
HIS A 237
 None
ZN  A 402 ( 3.2A)
ZN  A 402 ( 2.1A)
ZN  A 402 ( 3.3A)
 1.50A 6dchA-5vwmA:
undetectable		 6dchA-5vwmA:
21.45