SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 193
VAL A 191
TRP A 152
 None
 0.74A 1kqeA-5vwnA:
undetectable
1kqeE-5vwnA:
undetectable		 1kqeA-5vwnA:
undetectable
1kqeE-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 193
VAL A 191
TRP A 152
 None
 0.75A 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable		 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		3 / 3 TRP A 152
ALA A 193
VAL A 191
 None
 0.75A 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable		 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		3 / 3 TRP A 152
ALA A 193
VAL A 191
 None
 0.74A 1kqeA-5vwnA:
undetectable
1kqeE-5vwnA:
undetectable		 1kqeA-5vwnA:
undetectable
1kqeE-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 193
VAL A 191
TRP A 152
 None
 0.90A 1micA-5vwnA:
undetectable
1micB-5vwnA:
undetectable		 1micA-5vwnA:
undetectable
1micB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 TRP A  58
LEU A  27
GLY A   7
PHE A   5
ALA A  42
 None
 1.26A 2kceA-5vwnA:
undetectable		 2kceA-5vwnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 ILE A 238
PHE A 224
ALA A 216
ASN A 240
ASN A  35
 None
 1.07A 2rlcA-5vwnA:
undetectable		 2rlcA-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 ILE A 162
GLY A 168
GLY A 166
LEU A 124
VAL A 170
 None
 0.97A 2yvlB-5vwnA:
undetectable		 2yvlB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		4 / 7 GLY A 205
ALA A 176
ALA A 171
VAL A 221
 None
None
None
NA  A 301 (-4.6A)
 0.78A 3a2qA-5vwnA:
undetectable		 3a2qA-5vwnA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		4 / 7 ILE A 186
LYS A 181
ILE A 201
TYR A 118
 None
 1.18A 3eteD-5vwnA:
undetectable
3eteF-5vwnA:
undetectable		 3eteD-5vwnA:
10.61
3eteF-5vwnA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 10 VAL A 226
VAL A 239
ILE A 117
ASN A   9
GLY A   8
 None
 1.34A 3km6A-5vwnA:
undetectable		 3km6A-5vwnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		4 / 7 ILE A 117
GLY A   7
VAL A  39
SER A  61
 None
 0.95A 4a3uB-5vwnA:
6.7		 4a3uB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 VAL A 226
PHE A 224
GLY A   7
VAL A  38
PRO A 209
 None
 1.26A 4bvaA-5vwnA:
2.6		 4bvaA-5vwnA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 VAL A 226
PHE A 224
GLY A   7
VAL A  38
PRO A 209
 None
 1.31A 4bvaB-5vwnA:
2.6		 4bvaB-5vwnA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 106
ALA A 158
ILE A 195
LEU A 187
ILE A 144
 None
 1.02A 4kjjA-5vwnA:
undetectable		 4kjjA-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 12 THR A  84
ASN A   9
HIS A  88
ILE A  81
ASN A  64
 None
 1.39A 4pooB-5vwnA:
undetectable		 4pooB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5vwn TRIOSEPHOSPHATE
ISOMERASE
(Trichomonas
vaginalis) 		5 / 10 ILE A  81
GLY A  80
LEU A  50
LEU A  54
VAL A  60
 None
 1.12A 5twjB-5vwnA:
undetectable		 5twjB-5vwnA:
undetectable