SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.21A 1a52A-5vwsA:
2.5		 1a52A-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.21A 1a52B-5vwsA:
2.5		 1a52B-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 9 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1ereA-5vwsA:
undetectable		 1ereA-5vwsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 9 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1ereB-5vwsA:
undetectable		 1ereB-5vwsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 9 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1ereC-5vwsA:
2.0		 1ereC-5vwsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 9 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.29A 1ereD-5vwsA:
undetectable		 1ereD-5vwsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.26A 1gwrA-5vwsA:
undetectable		 1gwrA-5vwsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.22A 1pcgA-5vwsA:
undetectable		 1pcgA-5vwsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.19A 1pcgB-5vwsA:
2.8		 1pcgB-5vwsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1qkuA-5vwsA:
2.7		 1qkuA-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1qkuB-5vwsA:
2.7		 1qkuB-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.31A 1qkuC-5vwsA:
2.7		 1qkuC-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 PHE A 333
ALA A 332
THR A 235
LEU A 267
LEU A 345
 HEM  A 401 (-3.8A)
HEM  A 401 (-4.1A)
HEM  A 401 ( 3.9A)
None
HEM  A 401 (-3.8A)
 1.08A 2rctA-5vwsA:
undetectable		 2rctA-5vwsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		3 / 3 ALA A 230
THR A 234
CYH A 340
 HEM  A 401 (-3.5A)
HEM  A 401 (-3.7A)
HEM  A 401 (-2.3A)
 0.48A 3e4eA-5vwsA:
30.2		 3e4eA-5vwsA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		3 / 3 ALA A 230
THR A 234
CYH A 340
 HEM  A 401 (-3.5A)
HEM  A 401 (-3.7A)
HEM  A 401 (-2.3A)
 0.39A 3e4eB-5vwsA:
30.2		 3e4eB-5vwsA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		3 / 3 VAL A 210
LYS A 213
HIS A  83
 None
None
HEM  A 401 (-4.0A)
 0.46A 3elzA-5vwsA:
undetectable		 3elzA-5vwsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.23A 3erdA-5vwsA:
2.7		 3erdA-5vwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		4 / 5 SER A  98
ARG A 204
ARG A 198
GLY A 142
 None
 1.22A 3k9fA-5vwsA:
undetectable
3k9fB-5vwsA:
undetectable
3k9fC-5vwsA:
undetectable		 3k9fA-5vwsA:
21.83
3k9fB-5vwsA:
21.83
3k9fC-5vwsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 11 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.23A 3uudA-5vwsA:
2.7		 3uudA-5vwsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.22A 3uudB-5vwsA:
undetectable		 3uudB-5vwsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		3 / 3 TYR A 375
MET A 243
LEU A 124
 None
 1.02A 3vw1D-5vwsA:
undetectable		 3vw1D-5vwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		4 / 4 LEU A 114
LEU A 358
GLN A 108
GLU A 349
 None
None
None
HEM  A 401 ( 4.7A)
 1.16A 4i41A-5vwsA:
undetectable		 4i41A-5vwsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 ILE A 239
GLY A 346
GLY A 350
ILE A  99
LEU A 140
 None
HEM  A 401 ( 3.1A)
None
None
None
 1.12A 4mwzA-5vwsA:
undetectable		 4mwzA-5vwsA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 ILE A 239
GLY A 346
GLY A 350
ILE A  99
LEU A 140
 None
HEM  A 401 ( 3.1A)
None
None
None
 1.05A 4mwzB-5vwsA:
undetectable		 4mwzB-5vwsA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 PHE A 333
ALA A 332
THR A 235
LEU A 267
LEU A 345
 HEM  A 401 (-3.8A)
HEM  A 401 (-4.1A)
HEM  A 401 ( 3.9A)
None
HEM  A 401 (-3.8A)
 1.03A 4qynA-5vwsA:
undetectable		 4qynA-5vwsA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 11 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.24A 5dxbB-5vwsA:
2.8		 5dxbB-5vwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.23A 5dxeB-5vwsA:
2.9		 5dxeB-5vwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 11 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.21A 5dxgB-5vwsA:
2.7		 5dxgB-5vwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 GLU A 268
PHE A 374
ILE A 372
PHE A 380
GLY A  14
 None
 1.21A 5esgA-5vwsA:
29.0		 5esgA-5vwsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.24A 5hyrA-5vwsA:
undetectable		 5hyrA-5vwsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 11 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.24A 5hyrB-5vwsA:
undetectable		 5hyrB-5vwsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 9 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.25A 5wgdA-5vwsA:
2.7		 5wgdA-5vwsA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 10 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.22A 5wgqB-5vwsA:
undetectable		 5wgqB-5vwsA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		5 / 12 GLY A 346
PRO A 366
VAL A 136
PRO A 133
GLY A 231
 HEM  A 401 ( 3.1A)
None
None
None
HEM  A 401 (-2.8A)
 1.25A 6gngA-5vwsA:
undetectable		 6gngA-5vwsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5vws CYTOCHROME P450
(Thermobispora
bispora) 		4 / 8 PHE A 380
PHE A  18
HIS A 310
SER A 270
 None
 1.22A 6huoC-5vwsA:
2.7
6huoD-5vwsA:
undetectable		 6huoC-5vwsA:
11.05
6huoD-5vwsA:
12.09