SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 140
VAL A 138
ALA A 181
GLU A 143
 None
 0.97A 1dmiA-5vxcA:
undetectable
1dmiB-5vxcA:
undetectable		 1dmiA-5vxcA:
20.17
1dmiB-5vxcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 133
VAL A 108
CYH A  74
ALA A  86
 None
 1.20A 1mz9E-5vxcA:
undetectable		 1mz9E-5vxcA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 166
LEU A 133
VAL A 108
GLU A 117
LEU A 120
 None
 1.15A 2bxfA-5vxcA:
undetectable		 2bxfA-5vxcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS A  58
ASP A  55
ARG A  89
GLU A  56
 COA  A 401 (-4.3A)
None
None
None
 1.44A 2x8oA-5vxcA:
undetectable		 2x8oA-5vxcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 206
ASP A  76
PRO A 136
GLU A 171
 MG  A 402 (-3.1A)
None
None
MG  A 402 (-2.6A)
 1.38A 3l2wA-5vxcA:
undetectable		 3l2wA-5vxcA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 222
PHE A 284
SER A 285
ARG A 259
ALA A 262
 None
 1.20A 3lw5B-5vxcA:
undetectable		 3lw5B-5vxcA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 229
ARG A 226
GLY A 203
VAL A 244
 None
None
MG  A 402 ( 4.4A)
None
 1.01A 4oltA-5vxcA:
undetectable		 4oltA-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 229
ARG A 226
GLY A 204
VAL A 244
 None
 0.95A 4oltA-5vxcA:
undetectable		 4oltA-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 229
ARG A 226
GLY A 203
VAL A 244
 None
None
MG  A 402 ( 4.4A)
None
 1.09A 4oltB-5vxcA:
undetectable		 4oltB-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 229
ARG A 226
GLY A 204
VAL A 244
 None
 0.98A 4oltB-5vxcA:
undetectable		 4oltB-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 VAL A 106
VAL A 128
LEU A  72
LEU A  99
VAL A  91
 None
 1.26A 6czmB-5vxcA:
undetectable
6czmC-5vxcA:
undetectable		 6czmB-5vxcA:
25.00
6czmC-5vxcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  40
ARG A  45
ILE A  43
 None
 0.87A 6fgdA-5vxcA:
undetectable		 6fgdA-5vxcA:
21.40