SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		4 / 8 THR B  78
VAL B  79
ASN B  35
ALA B  32
 None
 1.17A 2ij7C-5vxjB:
undetectable		 2ij7C-5vxjB:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		5 / 12 MET B  34
ARG B  72
ASN B  77
VAL B  79
ALA B  98
 None
 0.76A 3qxtA-5vxjB:
19.3		 3qxtA-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		5 / 12 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
 None
 0.71A 3qxtA-5vxjB:
19.3		 3qxtA-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		7 / 12 VAL B   2
LEU B   4
ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.99A 3qxtB-5vxjB:
19.6		 3qxtB-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		7 / 12 VAL B   2
LEU B   4
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.69A 3qxtB-5vxjB:
19.6		 3qxtB-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		6 / 12 VAL B   2
MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
 None
 0.72A 3qxvA-5vxjB:
19.3		 3qxvA-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		6 / 12 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.82A 3qxvA-5vxjB:
19.3		 3qxvA-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		6 / 12 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.79A 3qxvB-5vxjB:
19.1		 3qxvB-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		6 / 11 VAL B   2
MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
 None
 0.71A 3qxvC-5vxjB:
19.5		 3qxvC-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		6 / 12 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.78A 3qxvD-5vxjB:
19.2		 3qxvD-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		5 / 12 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
 None
 0.61A 3qxvE-5vxjB:
15.7		 3qxvE-5vxjB:
63.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3
(Vicugna
pacos) 		4 / 7 ALA B  92
THR B  91
VAL B 115
GLU B  89
 None
 0.73A 5ecmD-5vxjB:
undetectable		 5ecmD-5vxjB:
12.52