SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		5 / 9 TYR A 276
LEU A 195
LEU A 174
ALA A 278
PHE A 283
 None
 1.19A 1tbfA-5vxlA:
undetectable		 1tbfA-5vxlA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		5 / 9 TYR A 276
LEU A 171
PHE A 167
LEU A 174
LEU A 195
 None
 1.37A 2bxeA-5vxlA:
2.4		 2bxeA-5vxlA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5vxl INVASIN IPAD
SINGLE-DOMAIN
ANTIBODY JPS-G3
(Shigella
flexneri;
Vicugna
pacos) 		4 / 8 LYS A 205
SER B  55
ASP B  52
ALA A 169
 None
 1.26A 2rk8A-5vxlA:
undetectable		 2rk8A-5vxlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		3 / 3 LEU A 263
TRP A 177
TYR A 276
 None
 1.00A 3aicF-5vxlA:
undetectable		 3aicF-5vxlA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5vxl INVASIN IPAD
SINGLE-DOMAIN
ANTIBODY JPS-G3
(Shigella
flexneri;
Vicugna
pacos) 		4 / 7 VAL A 170
LEU A 174
TYR B  54
ILE B  31
 None
 0.98A 3avpA-5vxlA:
undetectable		 3avpA-5vxlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		3 / 3 ASP A 287
PHE A 283
SER A 172
 None
 0.94A 3i5uB-5vxlA:
undetectable		 3i5uB-5vxlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		4 / 7 SER A  86
TYR A 301
ASN A 146
LEU A 150
 None
 1.43A 3lslA-5vxlA:
undetectable
3lslD-5vxlA:
undetectable		 3lslA-5vxlA:
21.36
3lslD-5vxlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vxl INVASIN IPAD
SINGLE-DOMAIN
ANTIBODY JPS-G3
(Shigella
flexneri;
Vicugna
pacos) 		4 / 4 LYS A 291
GLN A 165
ILE B  30
LEU A 174
 None
 1.08A 3qt0A-5vxlA:
undetectable		 3qt0A-5vxlA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		5 / 12 ALA B  24
MET B  34
ARG B  73
VAL B  80
ALA B  99
 None
 0.68A 3qxtA-5vxlB:
20.4		 3qxtA-5vxlB:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		7 / 12 LEU B   4
ALA B  24
MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
 None
 0.59A 3qxtB-5vxlB:
20.7		 3qxtB-5vxlB:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		7 / 12 ALA B  24
MET B  34
ARG B  73
ASN B  75
VAL B  80
ALA B  99
TYR B 106
 None
 0.68A 3qxvA-5vxlB:
20.2		 3qxvA-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		5 / 12 ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
 None
 0.71A 3qxvB-5vxlB:
20.1		 3qxvB-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		5 / 12 MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
 None
 0.57A 3qxvB-5vxlB:
20.1		 3qxvB-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		6 / 11 ALA B  24
MET B  34
ARG B  73
ASN B  75
VAL B  80
ALA B  99
 None
 0.74A 3qxvC-5vxlB:
20.3		 3qxvC-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		5 / 12 ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
 None
 0.69A 3qxvD-5vxlB:
20.2		 3qxvD-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		5 / 12 MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
 None
 0.60A 3qxvD-5vxlB:
20.2		 3qxvD-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		6 / 12 CYH B  22
ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
 None
 0.80A 3qxvE-5vxlB:
16.6		 3qxvE-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3
(Vicugna
pacos) 		6 / 12 CYH B  22
MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
 None
 0.66A 3qxvE-5vxlB:
16.6		 3qxvE-5vxlB:
66.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		5 / 9 LEU A 202
GLY A 235
ILE A 234
PRO A 252
ILE A 253
 None
 1.11A 3s56B-5vxlA:
undetectable		 3s56B-5vxlA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		5 / 12 LEU A 257
LEU A 260
LEU A 190
ILE A 253
VAL A 170
 None
 1.26A 4f4dA-5vxlA:
undetectable		 4f4dA-5vxlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		4 / 8 LEU A  96
THR A  50
LEU A  51
LEU A  47
 None
 0.74A 4z90F-5vxlA:
4.3
4z90G-5vxlA:
4.4
4z90H-5vxlA:
4.5
4z90I-5vxlA:
4.4
4z90J-5vxlA:
4.5		 4z90F-5vxlA:
20.06
4z90G-5vxlA:
20.06
4z90H-5vxlA:
20.06
4z90I-5vxlA:
20.06
4z90J-5vxlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5vxl INVASIN IPAD
(Shigella
flexneri) 		5 / 12 GLY A 267
GLY A 265
GLY A 264
LEU A 263
GLU A 268
 None
 0.91A 5c0oF-5vxlA:
undetectable		 5c0oF-5vxlA:
undetectable