SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 123
PRO H 153
THR H 122
PRO H 124
 None
 1.31A 1dsdC-5vxrH:
undetectable		 1dsdC-5vxrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 123
PRO H 153
THR H 122
PRO H 124
 None
 1.31A 1dsdC-5vxrH:
undetectable		 1dsdC-5vxrH:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 6 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.91A 1mt1A-5vxrH:
undetectable
1mt1F-5vxrH:
undetectable		 1mt1A-5vxrH:
30.43
1mt1F-5vxrH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 6 ILE H  67
ARG H  66
ASP H  89
LEU H  18
 None
 0.89A 1mt1B-5vxrH:
undetectable
1mt1C-5vxrH:
undetectable		 1mt1B-5vxrH:
20.72
1mt1C-5vxrH:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 6 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.88A 1mt1G-5vxrH:
undetectable
1mt1J-5vxrH:
undetectable		 1mt1G-5vxrH:
30.43
1mt1J-5vxrH:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.90A 1n13I-5vxrH:
undetectable
1n13L-5vxrH:
undetectable		 1n13I-5vxrH:
30.43
1n13L-5vxrH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ILE H  67
ARG H  66
ASP H  89
LEU H  18
 None
 0.88A 2qqcB-5vxrH:
undetectable
2qqcC-5vxrH:
undetectable		 2qqcB-5vxrH:
20.91
2qqcC-5vxrH:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.85A 2qqcA-5vxrH:
undetectable
2qqcF-5vxrH:
undetectable		 2qqcA-5vxrH:
30.43
2qqcF-5vxrH:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ILE H  67
ARG H  66
ASP H  89
LEU H  18
 None
 0.87A 2qqcD-5vxrH:
undetectable
2qqcE-5vxrH:
undetectable		 2qqcD-5vxrH:
20.91
2qqcE-5vxrH:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.87A 2qqcG-5vxrH:
undetectable
2qqcJ-5vxrH:
undetectable		 2qqcG-5vxrH:
30.43
2qqcJ-5vxrH:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.86A 2qqcI-5vxrH:
undetectable
2qqcL-5vxrH:
undetectable		 2qqcI-5vxrH:
30.43
2qqcL-5vxrH:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 7 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.92A 2qqdA-5vxrH:
undetectable
2qqdE-5vxrH:
undetectable		 2qqdA-5vxrH:
30.43
2qqdE-5vxrH:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER H 118
ALA H 120
PHE H 152
LEU H 176
 None
 0.17A 5mthA-5vxrH:
26.4		 5mthA-5vxrH:
undetectable