SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.35A 2eimJ-5vxzA:
undetectable		 2eimJ-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.37A 2eimW-5vxzA:
undetectable		 2eimW-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A 451
PHE A 311
LEU A 319
LEU A 348
VAL A 423
 None
 1.38A 2qd4A-5vxzA:
undetectable		 2qd4A-5vxzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vxz TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens) 		4 / 7 GLN C 109
ILE C  68
SER C 121
TYR C 108
 None
 1.34A 2xz5D-5vxzC:
undetectable
2xz5E-5vxzC:
undetectable		 2xz5D-5vxzC:
19.82
2xz5E-5vxzC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ILE C  90
ARG A 467
MET A 468
THR A 466
 None
 1.50A 3abkN-5vxzC:
undetectable
3abkW-5vxzC:
undetectable		 3abkN-5vxzC:
10.33
3abkW-5vxzC:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.34A 3ag2J-5vxzA:
undetectable		 3ag2J-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.33A 3ag4J-5vxzA:
undetectable		 3ag4J-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 339
GLN A 411
LEU A 359
ILE A 426
PHE A 428
 NAG  A 701 (-3.0A)
None
None
None
None
 1.43A 3mneA-5vxzA:
undetectable		 3mneA-5vxzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 339
GLN A 411
LEU A 359
ILE A 426
PHE A 428
 NAG  A 701 (-3.0A)
None
None
None
None
 1.37A 3mnoA-5vxzA:
undetectable		 3mnoA-5vxzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5vxz TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens) 		4 / 8 SER C  28
ASN C  33
GLN C  50
PHE C  30
 None
 1.21A 3n62A-5vxzC:
undetectable		 3n62A-5vxzC:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 10 TYR A 492
THR A 621
LEU A 525
LEU A 535
VAL A 579
 None
 1.31A 4c9nB-5vxzA:
undetectable		 4c9nB-5vxzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 9 TYR A 492
THR A 621
LEU A 525
LEU A 535
VAL A 579
 None
 1.35A 4c9pA-5vxzA:
undetectable		 4c9pA-5vxzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 ALA A 586
LEU A 608
SER A 536
LEU A 525
VAL A 507
 None
 1.17A 4eckB-5vxzA:
undetectable		 4eckB-5vxzA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 8 VAL A 306
TYR A 296
GLY A 303
GLY A 332
 None
None
None
CA  A 703 ( 4.7A)
 0.83A 5e26C-5vxzA:
undetectable
5e26D-5vxzA:
undetectable		 5e26C-5vxzA:
21.18
5e26D-5vxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens;
Homo
sapiens) 		4 / 4 VAL C  79
ALA C  92
ILE A 458
THR A 457
 None
 1.17A 5e4dB-5vxzC:
undetectable		 5e4dB-5vxzC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 ASP A 329
GLU A 331
ALA A 349
THR A 422
PRO A 439
 CA  A 703 (-2.2A)
None
None
None
None
 1.14A 5hnzB-5vxzA:
undetectable		 5hnzB-5vxzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ASP A 455
ARG A 310
ASN A 420
GLN C  76
 None
NAG  A 702 (-4.0A)
NAG  A 701 (-1.8A)
None
 1.29A 5l6eA-5vxzA:
undetectable		 5l6eA-5vxzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens) 		5 / 12 VAL C  79
LEU A 421
ARG A 299
GLY A 298
LEU A 297
 None
 1.15A 5m5cB-5vxzC:
undetectable		 5m5cB-5vxzC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vxz TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens) 		4 / 8 SER C  28
ASN C  33
GLN C  50
PHE C  30
 None
 1.23A 5vunA-5vxzC:
undetectable		 5vunA-5vxzC:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.40A 5wauJ-5vxzA:
undetectable		 5wauJ-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A 334
VAL A 423
VAL A 306
GLY A 298
THR A 666
 None
 1.24A 5x24A-5vxzA:
undetectable		 5x24A-5vxzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		4 / 5 TYR A 480
MET A 644
THR A 645
LEU A 646
 None
 1.36A 5z86J-5vxzA:
undetectable		 5z86J-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 505
GLU A 506
GLU A 585
 None
 0.79A 6fhwA-5vxzA:
undetectable		 6fhwA-5vxzA:
11.11