SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 10 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.23A 1a52A-5vy3A:
undetectable		 1a52A-5vy3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 10 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.23A 1a52B-5vy3A:
undetectable		 1a52B-5vy3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 9 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.22A 1ereA-5vy3A:
undetectable		 1ereA-5vy3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 9 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.21A 1ereB-5vy3A:
undetectable		 1ereB-5vy3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 9 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.22A 1ereC-5vy3A:
undetectable		 1ereC-5vy3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 9 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.20A 1ereD-5vy3A:
undetectable		 1ereD-5vy3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 12 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.21A 2yjaB-5vy3A:
undetectable		 2yjaB-5vy3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 12 ALA A 117
GLY A 155
LEU A 136
SER A 135
LEU A 112
 None
 1.37A 3bxoA-5vy3A:
undetectable		 3bxoA-5vy3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 12 TYR A 180
GLY A  39
LEU A 192
GLY A 193
ALA A 139
 None
 0.99A 3vywC-5vy3A:
undetectable		 3vywC-5vy3A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		4 / 4 LEU A  21
VAL A  24
GLU A  25
ARG A  28
 None
 1.11A 4ww7A-5vy3A:
undetectable		 4ww7A-5vy3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		6 / 12 GLY A 168
LYS A  32
VAL A 229
LEU A 233
GLY A 193
ILE A  49
 None
 1.41A 5vooA-5vy3A:
undetectable		 5vooA-5vy3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		6 / 12 GLY A 168
LYS A  32
VAL A 229
LEU A 233
GLY A 193
ILE A  49
 None
 1.34A 5vooB-5vy3A:
undetectable		 5vooB-5vy3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		6 / 12 GLY A 168
LYS A  32
VAL A 229
LEU A 233
GLY A 193
ILE A  49
 None
 1.38A 5vooC-5vy3A:
undetectable		 5vooC-5vy3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		5 / 12 LYS A  32
VAL A 229
LEU A 233
GLY A 193
ILE A  49
 None
 1.08A 5vooD-5vy3A:
undetectable		 5vooD-5vy3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		4 / 6 GLN A  68
VAL A  77
ALA A  37
THR A  36
 None
 0.89A 6cduB-5vy3A:
undetectable
6cduC-5vy3A:
undetectable		 6cduB-5vy3A:
22.63
6cduC-5vy3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vy3 PROTEASOME SUBUNIT
ALPHA
(Thermoplasma
acidophilum) 		4 / 7 GLN A  68
VAL A  77
ALA A  37
THR A  36
 None
 0.95A 6cduC-5vy3A:
undetectable
6cduD-5vy3A:
undetectable		 6cduC-5vy3A:
22.63
6cduD-5vy3A:
22.63