SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 ALA A 119
ALA A 118
LEU A  92
VAL A  55
LEU A 182
None
1.00A 1fm6A-5vydA:
undetectable
1fm6A-5vydA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
7 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
ILE A  61
LEU A 182
None
1.18A 1fm6U-5vydA:
undetectable
1fm6U-5vydA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.17A 1fm9A-5vydA:
undetectable
1fm9A-5vydA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.18A 1xiuA-5vydA:
undetectable
1xiuA-5vydA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.15A 1xlsA-5vydA:
undetectable
1xlsA-5vydA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.14A 1xlsB-5vydA:
undetectable
1xlsB-5vydA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.14A 1xlsC-5vydA:
undetectable
1xlsC-5vydA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.15A 1xlsD-5vydA:
undetectable
1xlsD-5vydA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
HIS A 126
MET A 195
LEU A 237
ASN A 239
PHE A 291
None
0.71A 1xlxA-5vydA:
40.4
1xlxA-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
HIS A 126
MET A 195
PHE A 258
PHE A 291
None
0.49A 1xlxB-5vydA:
40.4
1xlxB-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
ASP A 236
LEU A 237
PRO A 240
PHE A 258
PHE A 291
None
ZN  A 401 (-2.4A)
None
None
None
None
0.61A 1xmuA-5vydA:
39.9
1xmuA-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
ASP A 236
LEU A 237
TRP A 250
PHE A 258
PHE A 291
None
ZN  A 401 (-2.4A)
None
None
None
None
0.76A 1xmuA-5vydA:
39.9
1xmuA-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
PHE A 258
None
None
ZN  A 401 (-2.4A)
None
None
None
0.56A 1xmuB-5vydA:
40.4
1xmuB-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
PHE A 258
None
None
ZN  A 401 (-2.4A)
None
None
None
0.50A 1xmuB-5vydA:
40.4
1xmuB-5vydA:
29.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PHE A 258
PHE A 291
None
None
ZN  A 401 (-2.4A)
None
None
None
0.59A 1xomA-5vydA:
40.2
1xomA-5vydA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
LEU A 237
PHE A 258
PHE A 291
None
0.64A 1xomB-5vydA:
40.1
1xomB-5vydA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
PHE A 291
None
None
ZN  A 401 (-2.4A)
None
None
None
0.63A 1xoqA-5vydA:
40.1
1xoqA-5vydA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
ASP A 236
LEU A 237
PRO A 240
PHE A 291
None
ZN  A 401 (-2.4A)
None
None
None
0.53A 1xoqB-5vydA:
40.0
1xoqB-5vydA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
ASP A 236
LEU A 237
TRP A 250
PHE A 291
None
ZN  A 401 (-2.4A)
None
None
None
0.68A 1xoqB-5vydA:
40.0
1xoqB-5vydA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PHE A 258
PHE A 291
None
None
ZN  A 401 (-2.4A)
None
None
None
0.62A 1xosA-5vydA:
40.3
1xosA-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
LEU A 237
ASN A 239
PHE A 291
None
0.67A 1xotB-5vydA:
40.4
1xotB-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 4 VAL A  49
LEU A 124
ILE A 162
LEU A 163
None
0.95A 2byoA-5vydA:
undetectable
2byoA-5vydA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 6 ASP A  39
ARG A  74
THR A  75
LYS A  79
None
1.27A 2j2pE-5vydA:
undetectable
2j2pF-5vydA:
undetectable
2j2pE-5vydA:
20.75
2j2pF-5vydA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 10 ALA A 103
LEU A 313
LEU A 303
LEU A 231
LEU A 310
None
1.06A 2riwA-5vydA:
undetectable
2riwB-5vydA:
undetectable
2riwA-5vydA:
22.05
2riwB-5vydA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
LEU A 237
GLU A 257
PHE A 258
PHE A 291
None
0.67A 2weyA-5vydA:
38.2
2weyA-5vydA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  87
HIS A 122
PHE A 291
THR A 193
VAL A 296
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
None
MG  A 402 ( 4.9A)
None
1.19A 3czvA-5vydA:
undetectable
3czvB-5vydA:
undetectable
3czvA-5vydA:
20.29
3czvB-5vydA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
ASN A 239
PRO A 240
PHE A 291
None
0.71A 3g4lA-5vydA:
39.6
3g4lA-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
PHE A 291
None
None
ZN  A 401 (-2.4A)
None
None
None
0.51A 3g4lB-5vydA:
39.8
3g4lB-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
PHE A 291
None
None
ZN  A 401 (-2.4A)
None
None
None
0.61A 3g4lB-5vydA:
39.8
3g4lB-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
6 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
ASN A 239
PRO A 240
None
None
ZN  A 401 (-2.4A)
None
None
None
0.75A 3g4lC-5vydA:
39.7
3g4lC-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
None
None
ZN  A 401 (-2.4A)
None
None
0.49A 3g4lC-5vydA:
39.7
3g4lC-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
None
None
ZN  A 401 (-2.4A)
None
None
0.45A 3g4lD-5vydA:
39.5
3g4lD-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
None
None
ZN  A 401 (-2.4A)
None
None
0.43A 3g4lD-5vydA:
39.5
3g4lD-5vydA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 ALA A 119
LEU A  92
VAL A  55
ILE A  61
LEU A 182
None
0.96A 3h0aA-5vydA:
undetectable
3h0aA-5vydA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 7 HIS A  83
LEU A 284
PHE A 291
VAL A 295
None
0.43A 3jwqC-5vydA:
40.1
3jwqC-5vydA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 7 HIS A  87
LEU A 284
PHE A 291
VAL A 295
ZN  A 401 (-3.4A)
None
None
None
0.84A 3jwqC-5vydA:
40.1
3jwqC-5vydA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 8 TYR A  77
CYH A  46
TRP A  85
LEU A  42
None
1.42A 5kxiA-5vydA:
2.2
5kxiB-5vydA:
2.2
5kxiA-5vydA:
21.39
5kxiB-5vydA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 8 TYR A  77
CYH A  46
TRP A  85
LEU A  42
None
1.42A 5kxiD-5vydA:
undetectable
5kxiE-5vydA:
2.2
5kxiD-5vydA:
21.39
5kxiE-5vydA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
4 / 8 ALA A 235
PHE A 307
LEU A 310
VAL A 227
None
0.73A 5nujA-5vydA:
undetectable
5nujA-5vydA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
None
1.02A 5z12C-5vydA:
2.1
5z12C-5vydA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5vyd PHOSPHODIESTERASE
(Salpingoeca
rosetta)
5 / 12 ALA A 119
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.04A 5z12C-5vydA:
2.1
5z12C-5vydA:
14.83