SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 201
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.44A 1fo4A-5vyeA:
undetectable		 1fo4A-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.38A 1fo4A-5vyeA:
undetectable		 1fo4A-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 6 ALA A 224
PHE A  59
ILE A 216
VAL A 200
 None
 0.89A 2cizA-5vyeA:
undetectable		 2cizA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 8 GLY A 213
GLY A  64
THR A  65
ALA A  66
ALA A  67
 None
PLR  A 401 (-2.8A)
PLR  A 401 (-3.8A)
None
None
 0.64A 2ej3A-5vyeA:
undetectable		 2ej3A-5vyeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 10 GLY A 213
GLY A  64
THR A  65
ALA A  66
ALA A  67
 None
PLR  A 401 (-2.8A)
PLR  A 401 (-3.8A)
None
None
 0.67A 2ej3B-5vyeA:
undetectable		 2ej3B-5vyeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 8 LEU A 217
PHE A 219
THR A  54
ALA A 190
 None
 1.03A 3ax9B-5vyeA:
undetectable		 3ax9B-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 12 VAL A 148
GLY A 149
GLY A 291
ALA A 145
THR A 150
 None
 1.15A 3dh0A-5vyeA:
2.6		 3dh0A-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 12 GLY A 291
ALA A 181
ASP A 174
ASP A  11
GLY A 175
 None
None
PLR  A 401 (-2.6A)
None
None
 1.31A 3jzjA-5vyeA:
undetectable		 3jzjA-5vyeA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		3 / 3 ALA A 289
ARG A 177
LYS A 207
 None
PLR  A 401 (-3.9A)
PLR  A 401 (-2.3A)
 0.93A 3kp3B-5vyeA:
undetectable		 3kp3B-5vyeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 6 ALA A 110
ILE A  83
LEU A 117
GLU A 124
 None
 0.67A 3r9sC-5vyeA:
undetectable		 3r9sC-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 8 ALA A 110
ILE A  83
LEU A 117
GLU A 124
 None
 0.61A 3r9tA-5vyeA:
undetectable		 3r9tA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.36A 3unaA-5vyeA:
undetectable		 3unaA-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.36A 3unaB-5vyeA:
undetectable		 3unaB-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 201
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.45A 3uncA-5vyeA:
undetectable		 3uncA-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.39A 3uncA-5vyeA:
undetectable		 3uncA-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 201
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.45A 3uncB-5vyeA:
undetectable		 3uncB-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.40A 3uncB-5vyeA:
undetectable		 3uncB-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 8 TYR A 152
CYH A 164
VAL A  82
ILE A 122
 None
 1.16A 4aftD-5vyeA:
undetectable
4aftE-5vyeA:
undetectable		 4aftD-5vyeA:
18.78
4aftE-5vyeA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		3 / 3 LYS A 128
TYR A 134
ARG A 129
 None
 1.26A 4gc9A-5vyeA:
undetectable		 4gc9A-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 12 ALA A 215
LEU A 244
SER A 245
PHE A 178
GLY A 204
 None
 1.39A 5jglA-5vyeA:
2.7		 5jglA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 12 GLU A 147
ASP A 174
GLY A 175
ALA A 183
ASN A 265
 PLR  A 401 ( 4.0A)
PLR  A 401 (-2.6A)
None
None
None
 1.36A 5kbwA-5vyeA:
undetectable		 5kbwA-5vyeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		5 / 9 THR A 150
THR A 146
ILE A 142
THR A  87
SER A  85
 None
 1.46A 5muoA-5vyeA:
undetectable
5muoB-5vyeA:
undetectable
5muoC-5vyeA:
undetectable
5muoD-5vyeA:
undetectable
5muoE-5vyeA:
undetectable		 5muoA-5vyeA:
18.82
5muoB-5vyeA:
18.82
5muoC-5vyeA:
18.82
5muoD-5vyeA:
18.82
5muoE-5vyeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		4 / 5 LEU A 336
MET A 323
CYH A 267
ASP A 327
 None
 1.35A 5p9iA-5vyeA:
undetectable		 5p9iA-5vyeA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5vye L-THREONINE ALDOLASE
(Pseudomonas
putida) 		3 / 3 THR A 143
MET A 173
HIS A 172
 PLR  A 401 ( 3.3A)
None
None
 1.03A 5uunA-5vyeA:
undetectable		 5uunA-5vyeA:
undetectable