SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF
(Homo
sapiens) 		5 / 12 ARG A 159
LEU A 167
ALA A 163
LEU A 132
LEU A  55
 None
 1.25A 1og5A-5vykA:
undetectable		 1og5A-5vykA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF
(Homo
sapiens) 		5 / 12 PHE A 109
LEU A 113
THR A 146
ARG A 168
LEU A 136
 None
 1.14A 2g78A-5vykA:
undetectable		 2g78A-5vykA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF
(Homo
sapiens) 		3 / 3 GLU A1062
LEU A1065
ASP A1066
 None
 0.36A 3ko0A-5vykA:
undetectable		 3ko0A-5vykA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF
(Homo
sapiens) 		3 / 3 GLU A1062
LEU A1065
ASP A1066
 None
 0.22A 3ko0T-5vykA:
undetectable		 3ko0T-5vykA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF
(Homo
sapiens) 		5 / 11 ALA A 152
VAL A 122
LEU A 147
LEU A 135
TRP A 112
 None
 1.11A 5eb5A-5vykA:
undetectable		 5eb5A-5vykA:
undetectable