SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 9 THR A 148
GLY A 145
LEU A 152
ARG A 169
GLY A 164
 None
 1.35A 1jhyA-5vylA:
undetectable		 1jhyA-5vylA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 GLY A  99
LEU A  87
LEU A 106
ALA A 107
LEU A  33
 None
 1.31A 1jipA-5vylA:
undetectable		 1jipA-5vylA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 110
LEU A 163
ALA A 532
LEU A 105
ARG A 117
 None
 1.38A 1kt5A-5vylA:
undetectable		 1kt5A-5vylA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A  94
LEU A 157
ALA A 107
GLU A 108
ARG A 543
 None
 1.19A 1s9pB-5vylA:
undetectable		 1s9pB-5vylA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 HIS A 251
LEU A 310
ILE A 255
SER A 362
GLN A 293
 None
 1.48A 1xotB-5vylA:
undetectable		 1xotB-5vylA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 113
GLY A 112
LEU A 533
PRO A 227
 None
 0.80A 1ya4A-5vylA:
undetectable		 1ya4A-5vylA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 LEU A 113
GLY A 112
LEU A 533
PRO A 227
 None
 0.90A 1ya4B-5vylA:
undetectable		 1ya4B-5vylA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 ALA A 104
ALA A 107
LEU A  88
LEU A 152
ALA A 151
 None
 0.88A 2bxgB-5vylA:
undetectable		 2bxgB-5vylA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 ARG A 553
GLU A 102
PRO A 101
ALA A 540
 None
 1.19A 2ejgB-5vylA:
undetectable		 2ejgB-5vylA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 LEU A 509
ILE A 402
ILE A 460
ALA A 461
 None
 0.87A 2i30A-5vylA:
undetectable		 2i30A-5vylA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 LEU A 277
THR A 278
ILE A 255
HIS A 251
 None
 1.29A 2jfaB-5vylA:
undetectable		 2jfaB-5vylA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 ARG A 553
GLU A 102
PRO A 101
ALA A 540
 None
 1.04A 2zgwA-5vylA:
undetectable		 2zgwA-5vylA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 115
ALA A 228
ALA A  74
THR A 144
ILE A 176
 None
 1.16A 3dl9B-5vylA:
undetectable		 3dl9B-5vylA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 ARG A  28
ASP A  79
ASP A  23
 None
 0.87A 3jb2A-5vylA:
2.2		 3jb2A-5vylA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 6 LEU A 551
LEU A 552
PRO A 101
LEU A 105
 None
 1.09A 3q1eA-5vylA:
undetectable
3q1eC-5vylA:
undetectable		 3q1eA-5vylA:
13.57
3q1eC-5vylA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 ILE A 136
ILE A 140
VAL A 115
LEU A 118
 None
 0.71A 3r9vA-5vylA:
2.6
3r9vB-5vylA:
2.5		 3r9vA-5vylA:
18.73
3r9vB-5vylA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 509
GLY A 469
LEU A 470
PHE A 468
PHE A 484
 None
 1.34A 3tbgA-5vylA:
2.1		 3tbgA-5vylA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 THR A 483
ASN A 479
GLU A 473
 None
 0.75A 3v4tA-5vylA:
undetectable
3v4tC-5vylA:
undetectable		 3v4tA-5vylA:
24.46
3v4tC-5vylA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 224
GLY A 112
ILE A 140
VAL A 115
ALA A 161
 None
 1.02A 4a6dA-5vylA:
undetectable		 4a6dA-5vylA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 224
GLY A 112
ILE A 140
VAL A 115
ALA A 161
 None
 1.04A 4a6eA-5vylA:
undetectable		 4a6eA-5vylA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 ILE A 140
ALA A 172
PHE A 230
PRO A 123
 None
 1.04A 5m0oC-5vylA:
undetectable		 5m0oC-5vylA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 HIS A  95
ARG A 543
GLU A 108
ARG A 158
 None
 1.17A 6b8kA-5vylA:
undetectable		 6b8kA-5vylA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 HIS A  95
ARG A 543
GLU A 108
ARG A 158
 None
 1.05A 6b94A-5vylA:
undetectable		 6b94A-5vylA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 11 GLY A 156
ALA A 540
ALA A 104
PHE A 544
HIS A  95
 None
 1.41A 6qgbA-5vylA:
undetectable		 6qgbA-5vylA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5vyl INNER TEGUMENT
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 11 GLY A 156
ALA A 540
ALA A 104
PHE A 544
HIS A  95
 None
 1.42A 6qgbE-5vylA:
undetectable		 6qgbE-5vylA:
24.22