SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 HIS A  12
ALA A 140
GLY A 136
TYR A 139
 None
None
CL  A 307 (-3.6A)
0FX  A 302 (-3.8A)
 1.11A 1c8lA-5vyqA:
undetectable		 1c8lA-5vyqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  18
ALA A  15
HIS A  12
 None
 0.73A 1q23G-5vyqA:
undetectable		 1q23G-5vyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  18
ALA A  15
HIS A  12
 None
 0.72A 1q23L-5vyqA:
undetectable		 1q23L-5vyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  18
ALA A  15
HIS A  12
 None
 0.73A 1q23J-5vyqA:
undetectable		 1q23J-5vyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 202
LEU A 200
LEU A 182
GLU A 180
ALA A 211
 None
 1.39A 1sn0A-5vyqA:
undetectable
1sn0C-5vyqA:
undetectable		 1sn0A-5vyqA:
20.48
1sn0C-5vyqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 196
HIS A 195
ALA A 211
VAL A 223
PHE A 213
 None
 1.20A 2d06B-5vyqA:
undetectable		 2d06B-5vyqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  86
ARG A  90
ASP A 114
 None
 0.90A 2qe6A-5vyqA:
undetectable		 2qe6A-5vyqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  86
ARG A  90
ASP A 114
 None
 0.94A 2qe6B-5vyqA:
undetectable		 2qe6B-5vyqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 152
ILE A 157
HIS A  63
LEU A 142
TYR A 139
 None
None
0FX  A 302 (-3.8A)
None
0FX  A 302 (-3.8A)
 1.40A 3gwxB-5vyqA:
undetectable		 3gwxB-5vyqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 195
ASN A 198
ALA A 202
 None
EDO  A 303 (-3.1A)
None
 0.33A 5n4tB-5vyqA:
undetectable		 5n4tB-5vyqA:
21.98