SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ARG A 201
VAL A  37
TYR A  87
ASN A  46
HIS A  50
 GDP  A 303 (-3.7A)
None
None
None
None
 1.43A 1x70B-5vysA:
undetectable		 1x70B-5vysA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		4 / 9 ILE A  35
ALA A  18
VAL A  22
GLU A  19
 None
 0.83A 2vufA-5vysA:
undetectable		 2vufA-5vysA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 ARG A  88
ILE A 169
THR A 131
 GDP  A 303 (-3.0A)
None
None
 0.67A 3ia4D-5vysA:
undetectable		 3ia4D-5vysA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 TRP A 213
PHE A 221
PRO A 232
SER A 214
LEU A 235
 None
 1.04A 3iv6A-5vysA:
4.3		 3iv6A-5vysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 TRP A 213
PHE A 221
PRO A 232
SER A 214
LEU A 235
 None
 1.04A 3iv6C-5vysA:
4.4		 3iv6C-5vysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 11 VAL A  11
GLY A  13
TYR A  14
ALA A 172
LEU A  25
 None
 1.12A 3rc0A-5vysA:
undetectable		 3rc0A-5vysA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 PRO A 228
ILE A 169
HIS A  86
ARG A  45
GLY A  15
 None
None
None
GDP  A 303 (-2.6A)
None
 1.33A 4l9qA-5vysA:
undetectable		 4l9qA-5vysA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 LEU A  96
ASP A 184
THR A   7
VAL A 104
ARG A 137
 None
 1.46A 5dlvB-5vysA:
undetectable		 5dlvB-5vysA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 LEU A  25
LEU A 149
MET A  85
LEU A 176
CYH A  21
 None
 1.42A 5emlA-5vysA:
4.8		 5emlA-5vysA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 LEU A 164
ARG A  45
PRO A  17
ILE A 169
HIS A 136
 None
GDP  A 303 (-2.6A)
None
None
1YJ  A 301 (-4.5A)
 1.39A 5uhgC-5vysA:
undetectable		 5uhgC-5vysA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 TYR A 199
ALA A 113
TYR A 114
 None
 0.86A 5uunB-5vysA:
undetectable		 5uunB-5vysA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 ARG A  88
PHE A 165
ARG A  45
 GDP  A 303 (-3.0A)
GDP  A 303 ( 4.5A)
GDP  A 303 (-2.6A)
 1.14A 5y9yA-5vysA:
undetectable		 5y9yA-5vysA:
22.04