SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 HIS A 734
LEU A 539
SER A 538
ASP A 534
 MN  A1201 (-4.0A)
None
None
MN  A1201 (-2.8A)
 1.23A 1ismB-5vywA:
undetectable		 1ismB-5vywA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 VAL A   6
PRO A  80
HIS A 295
VAL A 291
 None
 1.20A 1jtvA-5vywA:
3.8		 1jtvA-5vywA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 PHE A 351
PHE A 452
PHE A 454
VAL A 237
 None
 0.86A 1lh6A-5vywA:
undetectable		 1lh6A-5vywA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ALA A  70
ILE A  66
ALA A  97
LEU A 107
PHE A  91
 None
 1.19A 1udtA-5vywA:
undetectable		 1udtA-5vywA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 LYS A 703
THR A 573
SER A 767
GLU A 810
 MN  A1201 (-3.1A)
None
None
None
 1.34A 1xr2B-5vywA:
undetectable		 1xr2B-5vywA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 LEU A 527
PRO A 769
VAL A 757
ILE A 755
 None
 1.00A 2aoiB-5vywA:
undetectable		 2aoiB-5vywA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 539
VAL A 802
SER A 761
LEU A 762
ASP A 796
 None
 1.15A 2c12C-5vywA:
undetectable		 2c12C-5vywA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 11 LEU A 539
VAL A 802
SER A 761
LEU A 762
ASP A 796
 None
 1.22A 2c12F-5vywA:
undetectable		 2c12F-5vywA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 10 TYR A 283
ILE A 285
ILE A 254
GLU A 274
ILE A 208
 None
 1.37A 2dm6A-5vywA:
undetectable
2dm6B-5vywA:
5.5		 2dm6A-5vywA:
14.93
2dm6B-5vywA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ALA A  70
ILE A  66
ALA A  97
LEU A 107
PHE A  91
 None
 1.13A 2h42B-5vywA:
undetectable		 2h42B-5vywA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 10 ILE A 212
VAL A 210
THR A 298
VAL A 304
ILE A 331
 None
 0.89A 2nnjA-5vywA:
undetectable		 2nnjA-5vywA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 11 THR A 748
ILE A 755
ILE A 741
ALA A 777
VAL A 525
 None
 1.12A 2qhfA-5vywA:
undetectable		 2qhfA-5vywA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 426
ILE A 430
LEU A 411
VAL A 391
THR A 395
 None
 1.31A 2qo6A-5vywA:
undetectable		 2qo6A-5vywA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 TYR A 685
VAL A 725
ALA A 713
THR A 743
LEU A 731
 None
 1.32A 2x2nC-5vywA:
undetectable		 2x2nC-5vywA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 LYS A 236
ASN A 288
ARG A 290
GLU A 294
 None
 0.84A 2ys6A-5vywA:
27.0		 2ys6A-5vywA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 GLN A 211
ALA A 270
GLN A 310
ILE A 306
 None
 1.29A 2z0aA-5vywA:
undetectable		 2z0aA-5vywA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 TYR A 680
ASP A 640
GLN A 647
GLU A 649
 None
 1.38A 3dh0A-5vywA:
undetectable		 3dh0A-5vywA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 LYS A 710
PRO A 711
SER A 745
LEU A 673
 None
 1.44A 3iluH-5vywA:
undetectable		 3iluH-5vywA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 ASN A 447
THR A 448
LEU A 451
ASN A 204
 None
 1.03A 3kp2A-5vywA:
undetectable
3kp2B-5vywA:
undetectable		 3kp2A-5vywA:
8.91
3kp2B-5vywA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 PHE A 351
ILE A 338
LEU A 411
ARG A 232
 None
 0.91A 3nxuA-5vywA:
undetectable		 3nxuA-5vywA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		3 / 3 TYR A 821
GLY A 707
ASP A 704
 None
 0.69A 3ou6C-5vywA:
3.0		 3ou6C-5vywA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 GLY A 765
THR A 766
ARG A 803
THR A 814
 None
 0.91A 3rglA-5vywA:
undetectable		 3rglA-5vywA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ILE A 633
TRP A 799
ILE A 552
MET A 596
 None
 1.16A 3welA-5vywA:
8.7		 3welA-5vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 LEU A 911
GLY A 909
ILE A 926
VAL A 927
 None
 0.86A 3wriA-5vywA:
undetectable		 3wriA-5vywA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 LEU A 911
GLY A 909
ILE A 926
VAL A 927
 None
 0.85A 3wriB-5vywA:
undetectable		 3wriB-5vywA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 LEU A 911
GLY A 909
ILE A 926
VAL A 927
 None
 0.79A 3wrkA-5vywA:
undetectable		 3wrkA-5vywA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
ARG A 637
HIS A 732
HIS A 734
SER A 538
 None
None
MN  A1201 (-4.0A)
MN  A1201 (-4.0A)
None
 1.39A 4aqlA-5vywA:
6.3		 4aqlA-5vywA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 ARG A 226
GLU A 209
GLU A 225
ARG A 251
 None
 0.88A 4bqfB-5vywA:
2.7		 4bqfB-5vywA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 727
VAL A 725
ALA A 689
ALA A 697
THR A 695
 None
 0.99A 4fiaA-5vywA:
undetectable		 4fiaA-5vywA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 727
VAL A 725
ALA A 689
ALA A 697
THR A 695
 None
 0.99A 4fiaA-5vywA:
undetectable		 4fiaA-5vywA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 ASN A 269
PRO A 105
GLN A 211
ILE A 220
 None
 1.03A 4iilA-5vywA:
2.6		 4iilA-5vywA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 8 ARG A  15
GLN A 211
GLY A 271
THR A 272
 None
 0.88A 4k87A-5vywA:
3.2		 4k87A-5vywA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 GLN A 768
ASP A 704
HIS A 732
SER A 538
LEU A 539
 None
None
MN  A1201 (-4.0A)
None
None
 1.41A 4kmuH-5vywA:
undetectable		 4kmuH-5vywA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ILE A 787
SER A 786
ASP A 529
ASP A 534
 None
None
None
MN  A1201 (-2.8A)
 1.14A 4krhB-5vywA:
2.1		 4krhB-5vywA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.28A 4lvcA-5vywA:
2.9		 4lvcA-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.33A 4lvcB-5vywA:
2.1		 4lvcB-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.30A 4lvcC-5vywA:
2.8		 4lvcC-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		7 / 7 LYS A 236
ASN A 288
ARG A 290
GLN A 292
VAL A 293
GLU A 294
ARG A 341
 None
 0.80A 4mv7A-5vywA:
54.8		 4mv7A-5vywA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.37A 4pfjA-5vywA:
undetectable		 4pfjA-5vywA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 246
ILE A 254
SER A 229
HIS A 224
HIS A 222
 None
 1.18A 5h1eA-5vywA:
undetectable		 5h1eA-5vywA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 389
VAL A 382
ILE A 416
GLY A 356
LEU A 371
 None
 1.18A 5ienA-5vywA:
undetectable		 5ienA-5vywA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 VAL A 515
LEU A 563
SER A 565
ILE A 556
 None
 1.06A 5jw1A-5vywA:
undetectable		 5jw1A-5vywA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ILE A 338
VAL A 404
ASN A 432
ASN A 428
ALA A 440
 None
 1.08A 5lg3E-5vywA:
undetectable		 5lg3E-5vywA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.35A 5m5kA-5vywA:
2.0		 5m5kA-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.33A 5m5kB-5vywA:
3.0		 5m5kB-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.26A 5m66B-5vywA:
3.1		 5m66B-5vywA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		3 / 3 HIS A 734
SER A 767
ARG A 533
 MN  A1201 (-4.0A)
None
MN  A1201 ( 4.5A)
 0.97A 5u63A-5vywA:
1.3		 5u63A-5vywA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 10 TYR A 776
ILE A 741
TYR A 775
TYR A 744
ILE A 755
 None
 1.45A 5u98D-5vywA:
3.7		 5u98D-5vywA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.32A 5v96A-5vywA:
2.0		 5v96A-5vywA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.32A 5v96B-5vywA:
2.8		 5v96B-5vywA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.31A 5v96C-5vywA:
2.8		 5v96C-5vywA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.30A 5v96D-5vywA:
2.0		 5v96D-5vywA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 ASN A 474
GLN A1051
ASP A1050
SER A1052
 None
BTN  A1202 ( 4.7A)
None
None
 1.28A 5w4zA-5vywA:
8.5		 5w4zA-5vywA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 THR A 464
LEU A 468
ILE A 471
THR A 472
 None
 0.92A 5zsfA-5vywA:
undetectable
5zsfB-5vywA:
undetectable		 5zsfA-5vywA:
5.85
5zsfB-5vywA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.33A 6aphA-5vywA:
2.2		 6aphA-5vywA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 4 GLY A 374
ARG A   9
ASN A 375
LEU A 389
 None
 0.95A 6b58A-5vywA:
undetectable		 6b58A-5vywA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 GLN A 768
ASP A 704
HIS A 732
SER A 538
LEU A 539
 None
None
MN  A1201 (-4.0A)
None
None
 1.41A 6ccvC-5vywA:
1.8		 6ccvC-5vywA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 GLY A1031
ASN A1049
ASP A1050
SER A1052
 None
 1.16A 6dwdA-5vywA:
undetectable
6dwdC-5vywA:
undetectable		 6dwdA-5vywA:
19.72
6dwdC-5vywA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.33A 6gbnA-5vywA:
undetectable		 6gbnA-5vywA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.35A 6gbnB-5vywA:
undetectable		 6gbnB-5vywA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 604
THR A 665
GLU A 567
ASP A 756
HIS A 730
 None
 1.34A 6gbnC-5vywA:
undetectable		 6gbnC-5vywA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 HIS A 207
HIS A 295
GLU A 209
GLU A  87
 None
 1.22A 6mn4F-5vywA:
undetectable		 6mn4F-5vywA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.46A 6mn5A-5vywA:
undetectable		 6mn5A-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.48A 6mn5C-5vywA:
undetectable		 6mn5C-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.40A 6mn5D-5vywA:
undetectable		 6mn5D-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 7 ARG A  15
GLU A  11
ASP A 372
CYH A 394
 None
 1.19A 6mn5E-5vywA:
undetectable		 6mn5E-5vywA:
6.01