SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 468
LEU J 469
LEU J 428
LEU J 501
THR J 491
 None
 1.28A 1a28B-5vzjJ:
undetectable		 1a28B-5vzjJ:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 PHE J 148
TYR J 307
PRO J 150
 None
 1.11A 1mcnA-5vzjJ:
undetectable
1mcnB-5vzjJ:
undetectable
1mcnP-5vzjJ:
undetectable		 1mcnA-5vzjJ:
16.01
1mcnB-5vzjJ:
16.01
1mcnP-5vzjJ:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 468
LEU J 469
LEU J 428
LEU J 501
THR J 491
 None
 1.26A 1zucB-5vzjJ:
undetectable		 1zucB-5vzjJ:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 11 ARG J 399
ARG J 407
SER J 404
PRO J 424
ILE J 419
 None
 1.36A 2a68M-5vzjJ:
0.0		 2a68M-5vzjJ:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 428
LEU J 468
ALA J 471
LEU J 501
LEU J 441
 None
 1.41A 2oaxD-5vzjJ:
undetectable		 2oaxD-5vzjJ:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 428
LEU J 468
ALA J 471
LEU J 501
LEU J 441
 None
 1.36A 2oaxE-5vzjJ:
undetectable		 2oaxE-5vzjJ:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 7 GLN J 345
TYR J 361
TYR J 344
ILE J 351
 A  M  17 ( 3.6A)
None
None
None
 1.34A 2ph9A-5vzjJ:
undetectable
2ph9B-5vzjJ:
undetectable		 2ph9A-5vzjJ:
16.99
2ph9B-5vzjJ:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 8 ILE J 140
GLU J 272
ASP J 303
GLY J 249
 None
 0.88A 2qqdB-5vzjJ:
undetectable
2qqdC-5vzjJ:
undetectable		 2qqdB-5vzjJ:
11.59
2qqdC-5vzjJ:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 9 PHE J 281
VAL J 396
GLY J 310
GLU J 184
ILE J 187
 None
 1.44A 2w98A-5vzjJ:
undetectable		 2w98A-5vzjJ:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 10 ILE J 235
LEU J 239
ILE J 256
PHE J 281
THR J 366
 None
 1.18A 2w9sC-5vzjJ:
undetectable		 2w9sC-5vzjJ:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 7 LYS J 230
LEU J 226
LEU J 277
THR J 282
 None
 1.01A 3ozkB-5vzjJ:
undetectable		 3ozkB-5vzjJ:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 HIS J 581
ARG J 578
GLU J 579
 None
 1.14A 3qf1A-5vzjJ:
undetectable		 3qf1A-5vzjJ:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 HIS J 181
SER J 413
GLU J 414
 None
 0.82A 3s8pA-5vzjJ:
undetectable		 3s8pA-5vzjJ:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 8 HIS J 326
GLY J 322
GLY J 388
ASN J 384
 A  M  14 ( 3.9A)
None
None
None
 0.94A 3v3nB-5vzjJ:
undetectable		 3v3nB-5vzjJ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 8 HIS J 326
GLY J 322
GLY J 388
ASN J 384
 A  M  14 ( 3.9A)
None
None
None
 0.93A 3v3nC-5vzjJ:
undetectable		 3v3nC-5vzjJ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 7 LYS J 230
LEU J 226
LEU J 277
THR J 282
 None
 0.94A 4iklA-5vzjJ:
undetectable
4iklB-5vzjJ:
undetectable		 4iklA-5vzjJ:
11.64
4iklB-5vzjJ:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 ASN J 497
LEU J 501
LEU J 468
ASN J 488
 None
 0.98A 4n09C-5vzjJ:
undetectable		 4n09C-5vzjJ:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 HIS J 316
VAL J 389
GLU J 392
VAL J 396
 None
 1.40A 4p6vB-5vzjJ:
undetectable
4p6vE-5vzjJ:
undetectable		 4p6vB-5vzjJ:
22.47
4p6vE-5vzjJ:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 7 LYS J 230
LEU J 226
LEU J 277
THR J 282
 None
 0.98A 4pwjB-5vzjJ:
undetectable		 4pwjB-5vzjJ:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 ILE J 297
LEU J 152
LYS J 155
VAL J 309
 None
 0.98A 5jmnB-5vzjJ:
undetectable		 5jmnB-5vzjJ:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 LEU J 354
TYR J 361
LEU J 253
GLU J 240
 None
None
None
A  M  17 ( 4.0A)
 1.22A 5weaA-5vzjJ:
undetectable		 5weaA-5vzjJ:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 TRP J 299
ILE J 297
ASP J 296
 None
None
A  M  16 ( 3.6A)
 0.89A 6i0y7-5vzjJ:
undetectable		 6i0y7-5vzjJ:
5.09