SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 12 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.27A 1hvyB-5vztB:
undetectable		 1hvyB-5vztB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 11 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.40A 1ju6A-5vztB:
undetectable		 1ju6A-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 9 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.40A 1ju6B-5vztB:
undetectable		 1ju6B-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 11 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.40A 1ju6D-5vztB:
undetectable		 1ju6D-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 10 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.35A 1jujA-5vztB:
undetectable		 1jujA-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 10 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.35A 1jujB-5vztB:
undetectable		 1jujB-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 10 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.35A 1jujC-5vztB:
undetectable		 1jujC-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 10 ILE B 145
ASN B 518
LEU B 160
GLY B 171
TYR B 174
 None
 1.35A 1jujD-5vztB:
undetectable		 1jujD-5vztB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 11 LEU B 138
ILE B 194
VAL B 162
GLY B 171
LEU B 146
 None
 1.28A 2bxeA-5vztB:
undetectable		 2bxeA-5vztB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 12 TYR B 509
VAL B 344
PHE B 491
PHE B 446
SER B 507
 None
None
None
None
DTT  B 602 ( 4.9A)
 1.44A 3apwA-5vztB:
3.4		 3apwA-5vztB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		4 / 5 HIS B 322
GLN B 342
GLY B 328
SER B 320
 PO4  B 603 ( 4.0A)
None
None
None
 1.16A 4fu8A-5vztB:
undetectable		 4fu8A-5vztB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 12 PHE B 192
LEU B 160
TRP B 149
ARG B 288
ASP B 224
 None
 1.38A 5nknA-5vztB:
3.8		 5nknA-5vztB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		4 / 8 ILE B 194
VAL B 164
GLU B 114
LEU B 139
 None
 0.78A 5og9A-5vztB:
undetectable		 5og9A-5vztB:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		4 / 7 GLN B 535
GLY B 340
ILE B 337
TYR B 309
 None
None
DTT  B 602 (-4.3A)
DTT  B 602 ( 4.9A)
 1.15A 5vlmC-5vztB:
undetectable		 5vlmC-5vztB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5vzt F-BOX ONLY PROTEIN
31
(Homo
sapiens) 		5 / 12 ILE B 337
TYR B 156
LEU B 269
GLY B 477
PHE B 478
 DTT  B 602 (-4.3A)
None
None
None
None
 0.97A 6r2eE-5vztB:
undetectable		 6r2eE-5vztB:
undetectable