SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
4 / 5 ILE A 156
PHE A 169
PHE A 168
ILE A 226
None
1.15A 2hjhA-5w0gA:
undetectable
2hjhA-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
4 / 6 ILE A 191
VAL A 153
PRO A 157
ALA A 198
None
0.57A 5cu6A-5w0gA:
undetectable
5cu6A-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
5 / 12 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
None
1.10A 5hw4A-5w0gA:
undetectable
5hw4A-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
5 / 11 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
None
1.10A 5hw4B-5w0gA:
undetectable
5hw4B-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
5 / 12 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
None
1.10A 5hw4C-5w0gA:
undetectable
5hw4C-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
4 / 8 LEU A 224
ILE A 156
PHE A 219
ALA A 198
None
0.91A 5m0oC-5w0gA:
undetectable
5m0oC-5w0gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
4 / 7 VAL A 189
ILE A 191
PRO A 157
ALA A 198
None
0.51A 5osrA-5w0gA:
undetectable
5osrA-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo
sapiens)
4 / 7 VAL A 189
ILE A 191
VAL A 153
ALA A 198
None
0.33A 5osrA-5w0gA:
undetectable
5osrA-5w0gA:
undetectable