SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 8 HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
 1.06A 1hwiB-5w0mA:
1.4		 1hwiB-5w0mA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 8 HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
 1.00A 1hwiC-5w0mA:
undetectable		 1hwiC-5w0mA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		3 / 3 LYS A1274
ASP A1344
CYH A1346
 U  H   1 ( 4.3A)
None
None
 1.37A 2br4F-5w0mA:
undetectable		 2br4F-5w0mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 10 GLY A1317
PHE A 997
VAL A1004
PHE A1329
TYR A1328
 None
 1.47A 3r6wA-5w0mA:
undetectable
3r6wB-5w0mA:
undetectable		 3r6wA-5w0mA:
20.05
3r6wB-5w0mA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 5 THR A1155
ILE A1160
PHE A1304
LEU A1168
 None
 1.22A 3tf1A-5w0mA:
1.0		 3tf1A-5w0mA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 9 ALA A1163
GLY A1291
LEU A1168
ASN A1287
ILE A1278
 U  H   3 ( 3.3A)
U  H   1 ( 3.6A)
None
None
None
 1.41A 3wdmA-5w0mA:
undetectable		 3wdmA-5w0mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 4 SER A1170
THR A1174
PHE A1052
LYS A1152
 SO4  A1401 (-2.8A)
IOD  A1404 (-3.7A)
None
SO4  A1401 ( 2.7A)
 1.32A 4m93B-5w0mA:
undetectable		 4m93B-5w0mA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 ARG A1165
CYH A1346
ILE A1353
ASP A1159
 None
None
U  H   1 ( 4.1A)
None
 1.16A 4w5qA-5w0mA:
undetectable		 4w5qA-5w0mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 ARG A1165
CYH A1346
ILE A1353
ASP A1159
 None
None
U  H   1 ( 4.1A)
None
 1.16A 4w5tA-5w0mA:
undetectable		 4w5tA-5w0mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 ARG A1165
CYH A1346
ILE A1353
ASP A1159
 None
None
U  H   1 ( 4.1A)
None
 1.20A 4z4dA-5w0mA:
2.2		 4z4dA-5w0mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 ALA A1172
SER A1170
ASP A1280
PRO A1281
 None
SO4  A1401 (-2.8A)
None
None
 0.99A 5c6pA-5w0mA:
undetectable		 5c6pA-5w0mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 5 PRO A1038
GLY A1039
THR A1040
LYS A1041
 None
 1.13A 5x23A-5w0mA:
undetectable		 5x23A-5w0mA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 6 PHE A1037
PRO A1038
GLY A1039
THR A1040
LYS A1041
 None
 0.95A 5x24A-5w0mA:
undetectable		 5x24A-5w0mA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 PRO A1038
GLY A1039
THR A1040
LYS A1041
 None
 1.02A 5xxiA-5w0mA:
undetectable		 5xxiA-5w0mA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 12 SER A1233
VAL A1004
LEU A1239
PHE A 997
LEU A 993
 None
 1.35A 6a93B-5w0mA:
undetectable		 6a93B-5w0mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 12 SER A1233
VAL A1004
LEU A1239
PHE A1318
LEU A 993
 None
 1.29A 6a93B-5w0mA:
undetectable		 6a93B-5w0mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		4 / 6 ARG A1165
CYH A1346
ILE A1353
ASP A1159
 None
None
U  H   1 ( 4.1A)
None
 1.15A 6cbdA-5w0mA:
undetectable		 6cbdA-5w0mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens) 		5 / 10 ILE A1120
ALA A1021
LEU A1059
LEU A1042
LEU A1044
 None
 1.02A 6f6nA-5w0mA:
undetectable
6f6nB-5w0mA:
undetectable		 6f6nA-5w0mA:
17.75
6f6nB-5w0mA:
10.03