SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 137
THR A 140
ASP A 192
GLY A 233
ILE A 238
 EDO  A 405 (-3.7A)
None
None
None
EDO  A 404 ( 4.9A)
 1.31A 1oltA-5w0tA:
undetectable		 1oltA-5w0tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 337
ALA A 309
ASP A 308
GLU A 312
 None
None
None
EDO  A 403 ( 4.3A)
 1.14A 2xrzA-5w0tA:
undetectable		 2xrzA-5w0tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 286
PHE A 281
ASP A 277
GLU A 280
 None
 1.11A 3kp6A-5w0tA:
undetectable
3kp6B-5w0tA:
undetectable		 3kp6A-5w0tA:
21.78
3kp6B-5w0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 281
ALA A 287
THR A 290
LEU A 301
 None
 1.02A 4ejgD-5w0tA:
undetectable		 4ejgD-5w0tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 119
SER A 118
ARG A 228
PRO A 114
 None
 1.24A 5b2oA-5w0tA:
0.0		 5b2oA-5w0tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 119
SER A 118
ARG A 228
PRO A 114
 None
 1.23A 5b2pA-5w0tA:
0.0		 5b2pA-5w0tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 255
ILE A  88
ILE A  93
PHE A  90
LEU A 103
 None
 0.97A 5e4dB-5w0tA:
undetectable		 5e4dB-5w0tA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5w0t PROTEIN MSP1
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 229
LEU A 223
ILE A 157
ALA A 181
MET A 177
 None
 1.25A 5og9A-5w0tA:
undetectable		 5og9A-5w0tA:
22.31