SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE
(Leptospira
interrogans) 		4 / 7 GLU A 136
ARG A 104
VAL A  99
ALA A 122
 CMP  A 201 (-2.7A)
None
None
None
 0.93A 1fo4B-5w10A:
undetectable		 1fo4B-5w10A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE
(Leptospira
interrogans) 		5 / 9 LEU A  17
ILE A 157
SER A  16
GLU A  36
LEU A  40
 None
 1.03A 3ai9X-5w10A:
undetectable		 3ai9X-5w10A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE
(Leptospira
interrogans) 		4 / 5 GLN A 155
PRO A 124
ILE A 126
ASP A 159
 None
 1.49A 4z4hA-5w10A:
undetectable		 4z4hA-5w10A:
11.83